p53/miR-34a调控网络在肿瘤中的作用

被引：8
|
作者：
梁辰 [1 ]
王萍 [1 ]
金由辛 [1 ]
马中良 [1 ]
机构：
[1] 上海大学生命科学学院
来源：
生命科学 | 2016年 / 28卷 / 04期
关键词：
miR-34a; p53; 信号通路; 肿瘤;
D O I：
10.13376/j.cbls/2016058
中图分类号：
R730 [一般性问题];
学科分类号：
100214 ;
摘要：
MicroRNA是重要的调控分子,长约22 nt,属于非编码RNA,对肿瘤的发生和发展起着重要的作用。miR-34a是研究比较清楚的microRNA,目前认为是重要的抑癌micro RNA。p53是一个重要的抑癌基因。p53与miR-34a形成的正反馈调控网络具有抑制肿瘤细胞生长、转移及抑制肿瘤干细胞的功能。现综述p53/miR-34a调控网络研究的最新进展,并探讨其在肿瘤诊断及治疗中的应用。
引用
收藏
页码：464 / 469
页数：6
相关论文
共 15 条
  • [1] Phytochemical regulation of the tumor suppressive microRNA, miR‐34a, by p53‐dependent and independent responses in human breast cancer cells[J] . Kris G. Hargraves,Lin He,Gary L. Firestone.Molecular Carcinogenesis . 2016 (5)
  • [2] The 1,2-Diaminocyclohexane Carrier Ligand in Oxaliplatin Induces p53-Dependent Transcriptional Repression of Factors Involved in Thymidylate Biosynthesis
    Kiyonari, Shinichi
    Iimori, Makoto
    Matsuoka, Kazuaki
    Watanabe, Sugiko
    Morikawa-Ichinose, Tomomi
    Miura, Daisuke
    Niimi, Shinichiro
    Saeki, Hiroshi
    Tokunaga, Eriko
    Oki, Eiji
    Morita, Masaru
    Kadomatsu, Kenji
    Maehara, Yoshihiko
    Kitao, Hiroyuki
    [J]. MOLECULAR CANCER THERAPEUTICS, 2015, 14 (10) : 2332 - 2342
  • [3] miR-34a inhibits the migration and invasion of esophageal squamous cell carcinoma by targeting Yin Yang-1
    Nie, Jihua
    Ge, Xin
    Geng, Yangyang
    Cao, Han
    Zhu, Wei
    Jiao, Yang
    Wu, Jinchang
    Zhou, Jundong
    Cao, Jianping
    [J]. ONCOLOGY REPORTS, 2015, 34 (01) : 311 - 317
  • [4] MicroRNA-34a overcomes HGF-mediated gefitinib resistance in EGFR mutant lung cancer cells partly by targeting MET
    Zhou, Jian-Ya
    Chen, Xi
    Zhao, Jing
    Bao, Zhang
    Chen, Xing
    Zhang, Pei
    Liu, Zhen-Feng
    Zhou, Jian-Ying
    [J]. CANCER LETTERS, 2014, 351 (02) : 265 - 271
  • [5] Hypofractionated radiotherapy induces miR-34a expression and enhances apoptosis in human nasopharyngeal carcinoma cells
    Long, Zhixiong
    Wang, Bin
    Tao, Dan
    Huang, Ying
    Tao, Zezhang
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2014, 34 (05) : 1388 - 1394
  • [6] Elevated microRNA-34a in obesity reduces NAD+ levels and SIRT1 activity by directly targeting NAMPT
    Choi, Sung-E
    Fu, Ting
    Seok, Sunmi
    Kim, Dong-Hyun
    Yu, Eunkyung
    Lee, Kwan-Woo
    Kang, Yup
    Li, Xiaoling
    Kemper, Byron
    Kemper, Jongsook K.
    [J]. AGING CELL, 2013, 12 (06) : 1062 - 1072
  • [7] A microRNA miR-34a-Regulated Bimodal Switch Targets Notch in Colon Cancer Stem Cells
    Bu, Pengcheng
    Chen, Kai-Yuan
    Chen, Joyce Huan
    Wang, Lihua
    Walters, Jewell
    Shin, Yong Jun
    Goerger, Julian P.
    Sun, Jian
    Witherspoon, Mavee
    Rakhilin, Nikolai
    Li, Jiahe
    Yang, Herman
    Milsom, Jeff
    Lee, Sang
    Zipfel, Warren
    Jin, Moonsoo M.
    Guemues, Zeynep H.
    Lipkin, Steven M.
    Shen, Xiling
    [J]. CELL STEM CELL, 2013, 12 (05) : 602 - 615
  • [8] miR-34a Sets the "Sweet Spot'' for Notch in Colorectal Cancer Stem Cells
    Winton, Douglas J.
    [J]. CELL STEM CELL, 2013, 12 (05) : 499 - 501
  • [9] MiR-34a inhibits proliferation and migration of breast cancer through down-regulation of Bcl-2 and SIRT1
    Li, Laisheng
    Yuan, Linjin
    Luo, Jinmei
    Gao, Jie
    Guo, Jiaoli
    Xie, Xiaoming
    [J]. CLINICAL AND EXPERIMENTAL MEDICINE, 2013, 13 (02) : 109 - 117
  • [10] ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression
    Ahn, Young-Ho
    Gibbons, Don L.
    Chakravarti, Deepavali
    Creighton, Chad J.
    Rizvi, Zain H.
    Adams, Henry P.
    Pertsemlidis, Alexander
    Gregory, Philip A.
    Wright, Josephine A.
    Goodall, Gregory J.
    Flores, Elsa R.
    Kurie, Jonathan M.
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (09): : 3170 - 3183
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