Conformational Changes in HL60 Cells during Differentiation and Apoptosis Induced by Genistein

被引：0
|
作者：
王钊
周江兵
孙素琴
刘明杰
张洪钧
机构：
来源：
TsinghuaScienceandTechnology | 2001年 / 03期
关键词：
genistein; HL60; conformational change; differentiation; apoptosis;
D O I：
暂无
中图分类号：
R733.7 [白血病];
学科分类号：
摘要：
Genistein can induce not only differentiation but also apoptosis in HL60 human leukemia cells. During the differentiation and apoptosis, the HL60 cells undergo some conformational changes. Fourier transform infrared (FT IR) was employed to detect those changes. The results showed that the contents of DNA/protein and glycoprotein/protein increased. The α helix of the membrane protein also increased. In addition, the CO (H) stretching mode of serine, threonine and tyrosine residues of the cell proteins also changed. Those conformational changes suggest some mechanisms for how genistein affects the HL60 cells. 
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页码：243 / 247
页数：5
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