Inhibition of Yuyihe Powder on Tumor Growth in Mice Models of Sarcoma 180

被引：0

作者：

Jun-ling Li ^{[1
,2
]}

Shi-li Wang ^{[1
]}

Jin-xiang Han ^{[1
]}

Hai Xu ^{[2
]}

Xiao-bin Xu ^{[1
]}

Jun-ying Xue ^{[1
]}

机构：

[1] Key Laboratory of Ministry of Public Health for Biotech-Drug,Shandong Medicinal Biotechnology Center,Shandong Academy of Medical Sciences

[2] State Key Laboratory of Heavy Oil Processing and Centre for Bioengineering and Biotechnology,China University of Petroleum (East China)

来源：

Chinese Herbal Medicines | 2017年 / 9卷 / 02期

关键词：

antitumor effect; mice model; Sarcoma; 180; traditional Chinese medicine recipe; Yuyihe Powder;

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

1008 ;

摘要：

Objective To explore the antitumor effect of Yuyihe Powder(Yu Yi He San,YYHS) and its antitumor mechanism.Methods After treatment,tumor weight,immune apparatus weight,the life span of transplanted animals,spleen lymphocyte proliferation assays,and IL-2 concentration in mouse serum were recorded or detected.Results YYHS showed strong antitumor ability.Compared with control group,mid-dose YYHS(1.0g/kg) could inhibit the tumor growth,prolong the life span of S180-bearing mice to some extent,significantly increase the thymic and splenic indices of S180 mice,and strongly promote the secretion of IL-2 in blood;The inhibitory rate on tumor growth and life prolongation rate were 37.1%and 38.37%,respectively.Conclusion YYHS could not only significantly inhibit the growth of S180 cells,but also markedly prolong the survival time of S180 bearing mice.The mechanism of antitumor effect could obviously enhance immunologic function of the S180 bearing mice to inhibit the growth of S180 cells.

引用

页码：183 / 187

页数：5

共 50 条

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[J]. Chinese Herbal Medicines, 2017, (02) - 187
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