Clinical Significance of REM Sleep Behavior Disorders and Other Non-motor Symptoms of Parkinsonism

被引:0
|
作者
Hong Jin [1 ]
Jin-Ru Zhang [1 ]
Yun Shen [1 ]
Chun-Feng Liu [1 ,2 ]
机构
[1] Department of Neurology and Sleep Center, The Second Affiliated Hospital of Soochow University
[2] Institute of Neuroscience, Soochow University
基金
中国国家自然科学基金;
关键词
Parkinson’s disease; Rapid eye movement sleep behavior disorder; Risk factors; Parkinsonism;
D O I
暂无
中图分类号
R742.5 [震颤麻痹综合征];
学科分类号
1002 ;
摘要
Rapid eye movement sleep behavior disorder(RBD) is one of the most common non-motor symptoms of parkinsonism, and it may serve as a prodromal marker of neurodegenerative disease. The mechanism underlying RBD is unclear. Several prospective studies have reported that specific non-motor symptoms predict a conversion risk of developing a neurodegenerative disease, including olfactory dysfunction, abnormal color vision, autonomic dysfunction, excessive daytime sleepiness, depression, and cognitive impairment. Parkinson’s disease(PD) with RBD exhibits clinical heterogeneity with respect to motor and non-motor symptoms compared with PD without RBD. In this review, we describe the main clinical and pathogenic features of RBD, focusing on its association with other non-motor symptoms of parkinsonism.
引用
收藏
页码:576 / 584
页数:9
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