HIV-1核壳体蛋白NCp7抑制剂研究新进展

被引:3
|
作者
贾海永
俞霁
刘昕浩
张健
展鹏
刘新泳
机构
[1] 山东大学药学院药物化学研究所化学生物学教育部重点实验室
关键词
艾滋病; HIV-1; NCp7; 抑制剂; 药物设计;
D O I
10.16438/j.0513-4870.2017-0460
中图分类号
R978.7 [抗病毒药物];
学科分类号
摘要
艾滋病主要是由人免疫缺陷病毒I型(human immunodeficiency virus type 1,HIV-1)感染引起的全身性免疫功能丧失综合征。HIV-1核壳体蛋白7(nucleocapsid protein 7,NCp7)在病毒的逆转录过程和整合过程都发挥着重要作用。由于NCp7的保守性,基于此靶点的抑制剂不易产生耐药性。本综述介绍了近10年来所报道的HIV-1 NCp7抑制剂的研究新进展。
引用
收藏
页码:1652 / 1659
页数:8
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