Hepatotoxicity of anti-inflammatory and analgesic drugs:ultrastructural aspects

With the increasing incidence of drug-induced liver disease,attempts are beingmade to better understand the mechanisms behind these frequently life-endan-gering reactions.Analgesics and anti-inflammatory drugs are a major group ex-hibiting hepatotoxicity.We review research relating to these reactions,focusingon ultrastructural findings,which may contribute to the comprehension and pos-sible avoidance of drug-induced liver disease.We also present some originalobservations on clinical material and cultured cells exposed to acetaminophenalone or in combination with the antioxidant N-acetylcysteine or the P-glycopro-tein inhibitor verapamil.