Atherton-Todd反应的研究进展

被引：3
|
作者：
方思强 [1 ]
刘赞娇 [1 ]
王天利 [1 ,2 ]
机构：
[1] 四川大学化学学院绿色化学与技术教育部重点实验室
[2] 北京国家分子科学中心
来源：
有机化学 | 2023年 / 43卷 / 03期
基金：
国家重点研发计划;
关键词：
有机磷化合物; Atherton-Todd反应; 活性中间体; 不对称催化;
D O I：
暂无
中图分类号：
O621.25 [];
学科分类号：
摘要：
磷酰胺或磷酸酯类化合物及其衍生物是一类非常重要的含磷有机分子,在药物化学、材料化学以及有机催化等研究领域均有着广泛应用.Atherton-Todd反应是制备这类化合物最有效的方法之一,该反应是指氧磷氢化合物[P(O)-H]在碱的作用下与四氯化碳原位生成磷酰氯[P(O)-Cl]中间体,随后该中间体与醇或胺类化合物反应形成相应的磷酸酯或磷酰胺类化合物及其衍生物.近年来,Atherton-Todd反应由于其操作容易、原子经济性高、底物普适性广以及易于将含磷原子引入到活性化合物结构片段中等优点,受到了合成化学家的广泛关注.总结近几十年来Atherton-Todd反应的研究进展及其在有机合成中的应用,并对目前该领域可能存在的研究挑战提出展望,希望能为Atherton-Todd反应的未来发展方向提供一些借鉴和思考.
引用
收藏
页码：1069 / 1083
页数：15
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