Diabetes mellitus related bone metabolism and periodontal disease

被引：0

作者：

Ying-Ying Wu ^{[1
,2
]}

E Xiao ^{[2
,3
]}

Dana T Graves ^{[2
]}

机构：

[1] State Key Laboratory of Oral Diseases,West China Hospital of Stomatology,Sichuan University

[2] School of Dental Medicine,University of Pennsylvania

[3] Department of Oral and Maxillofacial Surgery,Peking University School and Hospital of Stomatology

来源：

International Journal of Oral Science | 2015年 / 7卷 / 02期

关键词：

bone loss; diabetes mellitus; hyperglycemia; inflammation; osseous; osteoblast; osteoclast; periodontitis;

D O I：

暂无

中图分类号：

R587.1 [糖尿病]; R781.4 [牙周病];

学科分类号：

1002 ; 100201 ; 100302 ;

摘要：

Diabetes mellitus and periodontal disease are chronic diseases affecting a large number of populations worldwide.Changed bone metabolism is one of the important long-term complications associated with diabetes mellitus.Alveolar bone loss is one of the main outcomes of periodontitis,and diabetes is among the primary risk factors for periodontal disease.In this review,we summarise the adverse effects of diabetes on the periodontium in periodontitis subjects,focusing on alveolar bone loss.Bone remodelling begins with osteoclasts resorbing bone,followed by new bone formation by osteoblasts in the resorption lacunae.Therefore,we discuss the potential mechanism of diabetes-enhanced bone loss in relation to osteoblasts and osteoclasts.

引用

页码：63 / 72

页数：10

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