Low Shear Stress Induces Inflammatory Response via CX3CR1/NF-κB Signaling Pathway in Human Umbilical Vein Endothelial Cells

被引：0

作者：

REN Peile ^{[1
]}

ZHAO Yiwei ^{[2
]}

ZHANG Daifang ^{[3
]}

Shafiu Adam.Shinge ^{[3
]}

YU Fengxu ^{[3
]}

NIE Yongmei ^{[3
]}

机构：

[1] Department of Physiology,Sanquan College of Xinxiang Medical University

[2] Department of physiology,School of Medicine,Huanghe Science and Technology College

[3] Department of Cardiovascular Surgery,Affiliated Hospital of the Southwest Medical University

来源：

医用生物力学 | 2021年 / S1期

基金：

中国国家自然科学基金;

关键词：

D O I：

暂无

中图分类号：

R318.01 [生物力学];

学科分类号：

0831 ;

摘要：

Objective The objective was to identify the comprehensive molecular circuitry involved in LSS-induced inflammation in human umbilical vein endothelial cells( HUVECs) through protein profiling and cell function experiments. Methods Western blotting was used to detect the expression of protein in HUVECs. qR T-PCR was used to detect the expression of mR NA. Monocyte adhesion test and scratch test was used to detect the effect of low shear stress on monocyte adhesion and cell migration. Results Western blot analysis revealed a significant increase in the expression of CX3 CR1, nuclear p65,

引用

页码：306 / 306

页数：1