Structure and antibacterial property of a new diterpenoid from Euphorbia helioscopia

被引：0
|
作者：
GENG Di [1 ]
YI Li-Tao [1 ]
SHI Yao [2 ]
MIN Zhi-Da [2 ]
机构：
[1] College of Chemical Engineering, Huaqiao University
[2] Department of Natural Medicinal Chemistry, China Pharmaceutical University
来源：
Chinese Journal of Natural Medicines | 2015年 / 13卷 / 09期
基金：
中国国家自然科学基金; 中央高校基本科研业务费专项资金资助;
关键词：
Euphorbia helioscopia; Jatrophone-type diterpenoid; Euphoheliosnoid E; Anti-microbial activity;
D O I：
暂无
中图分类号：
R285 [中药药理学];
学科分类号：
摘要：
The present study was designed to isolate and evaluate the antibacterial activity of the compounds from the whole plant of Euphorbia helioscopia L.. Various chromatographic techniques were used to isolate and purify the compound. The structure of the compound was elucidated on basis of spectral data(1H NMR, 13 C NMR, 1H-1H COSY, HSQC, HMBC, NOESY, IR, and HR-ESI-MS). A new jatrophone-type diterpenoid(14α,15β-diacetoxy-3β-benzoyloxy-7β-nicotinoyloxy-9-oxo-jatropha-5E,11E-diene), named euphoheliosnoid E(1), was isolated from the whole plant of E. helioscopia L. Compound 1 showed significant anti-microbial activity against oral pathogens.
引用
收藏
页码：704 / 706
页数：3
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