FTO、IRX3/5, 孰是孰非？

被引：2
|
作者：
王计秋 [1 ,2 ]
宁光 [1 ,2 ]
机构：
[1] 上海市内分泌代谢病研究所
[2] 上海市内分泌代谢病临床医学中心
来源：
中华内分泌代谢杂志 | 2015年 / 31卷 / 12期
关键词：
肥胖症; 遗传学; FTO; IRX3; IRX5; 全基因组关联研究;
D O I：
暂无
中图分类号：
R589.2 [脂肪代谢障碍];
学科分类号：
摘要：
多项针对肥胖症的大规模全基因组关联研究(GWAS)结果表明, 位于FTO基因1号内含子的多个多态性位点与肥胖发生风险密切相关, 不仅是所有GWAS关联位点中统计学差异最为明显的, 且是效应最强的一簇;后续临床、动物模型或分子生物学研究也支持FTO在肥胖发生中的重要作用。然而, 《The New England Journal of Medicine》杂志刚刚公布的一项研究表明, 这些关联位点的真正效应基因是IRX3/5, 这2个基因表达水平改变才是导致该风险位点被反复证明与肥胖相关的原因。我们该如何看待这一肥胖遗传学研究中最引人注目的事件?究竟谁是普通型肥胖症的元凶?这些问题尚待探究。
引用
收藏
页码：1013 / 1016
页数：4
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