THE STUDIES OF MALIGNANT TRANSFORMATION OF HUMAN EPITHELIAL CELLS INDUCED BY DIETHYL-NITROSAMINE (NDEA) IN VITRO

被引：0
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作者：
黄明
王秀琴
王志华
周传农
吴旻
机构：
[1] Beijing
[2] Cancer Institute
[3] Chinese Academy of Medical Sciences
来源：
Science China Chemistry | 1986年 / Ser.B1986卷 / 11期
关键词：
NDEA; THE STUDIES OF MALIGNANT TRANSFORMATION OF HUMAN EPITHELIAL CELLS INDUCED BY DIETHYL-NITROSAMINE; IN VITRO;
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摘要：
This is the first report on the diethylnitrosamine-induced malignant transformaton of hu-man epithelial cells derived from fetal kidney. The transformed cells have prolonged life span and aneuploid karyotypes. They also form anchorage independent colonies in soft agar. With additional one or two NDEA treatments, those cells could elicit poorly differontiated carcinomas in immunosuppressed new-born rats. This experiment indicates that the human fetal kidney cells seem to be a good material for studying the mechanisms of carcinogenesis of human epithelial cell.
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页码：1186 / 1191
页数：6
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