Prognostic factors influencing clinical outcomes of glioblastoma multiforme

Background Glioblastoma multiforme (GBM) is the most malignant kind of astrocytic tumors and is associated with apoor prognosis.In this retrospective study,we assessed the clinical,radiological,genetic molecular and treatment factorsthat influence clinical outcomes of patients with GBM.Methods A total of 116 patients with GBM who received surgery and radiation between January 2006 and December2007 were included in this study.Kaplan-Meier survival analysis and Cox regression analysis were used to find thefactors independently influencing patients’ progression free survival (PFS) time and overall survival (OS) time.Results Age,preoperative Karnofsky Performance Scale (KPS) score,KPS score change at 2 weeks after operation,neurological deficit symptoms,tumor resection extent,maximal tumor diameter,involvement of eloquent cortex or deepstructure,involvement of brain lobe,Ki-67 expression level and adjuvant chemotherapy were statistically significantfactors (P <0.05) for both PFS and OS in the univariate analysis.Cox proportional hazards modeling revealed that age≤50 years,preoperative KPS score ≥80,KPS score change after operation ≥0,involvement of single frontal lobe,non-eloquent area or deep structure involvement,low Ki-67 expression and adjuvant chemotherapy were independentfavorable factors (P <0.05) for patients’ clinical outcomes.Conclusions Age at diagnosis,preoperative KPS score,KPS score change at 2 weeks postoperation,involvement ofbrain lobe,involvement of eloquent cortex or deep structure,Ki-67 expression level and adjuvant chemotherapy correlatesignificantly with the prognosis of patients with GBM.