Sirtuin Functions in the Brain:From Physiological to Pathological Aspects

被引：0

作者：

邵家骧 ^{[1
,2
,3
]}

张婷婷 ^{[2
,3
]}

刘腾远 ^{[2
,3
]}

全亦周 ^{[1
,2
,3
]}

李凡 ^{[2
,3
]}

刘杰 ^{[1
,2
,3
]}

杨霄 ^{[2
,3
]}

谢谦 ^{[2
,3
]}

夏伟梁 ^{[1
,2
,3
]}

机构：

[1] State Key Laboratory of Oncogenes and Related Genes,Renji-Med X Clinical Stem Cell Research Center,Renji Hospital,Shanghai Jiaotong University School of Medicine

[2] School of Biomedical Engineering,Shanghai Jiaotong University

[3] Med-X Research Institute,Shanghai Jiaotong University

来源：

Journal of Shanghai Jiaotong University(Science) | 2014年 / 19卷 / 06期

基金：

中国国家自然科学基金;

关键词：

sirtuin; neural development; hypothalamic function; stroke; neurodegeneration;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

100104 ;

摘要：

Sirtuins are a family of nicotinamide adenine dinucleotide(NAD+) dependent deacetylases involved in multiple biological functions including metabolism, inflammation, stress resistance and aging. In mammals,there are seven members(Sirt1—Sirt7), with diversities in their subcellular localizations and enzymatic activities.Here, we review the functions of sirtuins, with a focus on their roles in normal brain physiology such as neural development regulation, body homeostasis maintenance, and memory formation. We also discuss the role of sirtuins in a variety of brain diseases including stroke, Alzheimer’s, Parkinson’s, and motor neuron dysfunction.Because of the emerging functions of sirtuins in brain physiology and pathology, drugs targeting sirtuins may offer potential therapeutic values for brain disorders.

引用

页码：651 / 662

页数：12

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