Synthesis and biological activities of some fluorine- and piperazine-containing 1,2,4-triazole thione derivatives

被引：4

作者：

Li-Yuan Zhang ^{[1
]}

Bao-Lei Wang ^{[1
]}

Yi-Zhou Zhan ^{[1
]}

Yan Zhang ^{[1
]}

Xiao Zhang ^{[1
]}

Zheng-Ming Li ^{[1
]}

机构：

[1] State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering, Nankai University

来源：

Chinese Chemical Letters | 2016年 / 27卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Triazole thione derivatives; Fluorine; Piperazine; Mannich base; Biological activity;

D O I：

暂无

中图分类号：

O626 [杂环化合物];

学科分类号：

070303 ; 081704 ;

摘要：

A series of fluorine- and piperazine-containing 1,2,4-triazole thione derivatives were synthesized by the Mannich reaction of triazole intermediates with various substituted piperazines and formaldehyde in high yields. Structures of title compounds were confirmed by melting points, IR,~1H NMR,C NMR and elemental analysis. The preliminary bioassays for 17 novel title compounds showed that several compounds have significant fungicidal activity against Cercospora arachidicola, Physalospora piricola and Rhizoctonia cerealis at 50 mg/m L.

引用

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页码：163 / 167

页数：5

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