Conditional Genome Editing in the Mammalian Brain Using CRISPR-Cas9

被引：0

作者：

Haojie Sun ^{[1
,2
]}

Jie Zheng ^{[3
]}

Ming Yi ^{[1
]}

You Wan ^{[1
,2
]}

机构：

[1] Neuroscience Research Institute, Department of Neurobiology, School of Basic Medical Sciences,Peking University

[2] Key Laboratory for Neuroscience, Ministry of Education/National Health Commission of China, Peking University

[3] Department of Pathophysiology, Huazhong University of Science and Technology

来源：

Neuroscience Bulletin | 2021年 / 37卷 / 03期

基金：

北京市自然科学基金; 中国国家自然科学基金;

关键词：

D O I：

暂无

中图分类号：

Q78 [基因工程（遗传工程）];

学科分类号：

071007 ; 0836 ; 090102 ;

摘要：

Neuronal ensembles with distinct morphological, biochemical, and functional identities are organized into complex circuits in the mammalian brain, and malfunction of specific neuronal types in different networks contributes to diverse pathological symptoms. Taking memory as an example, specific memories are held in a subset of neurons,referred to as engram cells.

引用

页码：423 / 426

页数：4

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