Learning From Biomarkers in Victims Accidentally Exposed to Ionizing Radiation

被引：0
|
作者：
Yan Wang [1 ]
Liqing Du [1 ]
Chang Xu [1 ]
Qin Wang [1 ]
Zhiyi Song [2 ]
Jianxiang Liu [3 ]
Xu Su [3 ]
Qiang Liu [1 ]
机构：
[1] Tianjin Key Laboratory of Molecular Nuclear Medicine,First Clinical Department of Medical Emergency Response Center for Nuclear Accident,Ministry of Health,Institute of Radiation Medicine,Chinese Academy of Medical Sciences,Peking Union Medical College
[2] Department of Radiology,Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital
[3] National Institute for Radiological Protection and Nuclear Safety,Chinese Center for Disease Control,Medical Emergency Response Center for Nuclear Accident,Ministry of Health
来源：
国际放射医学核医学杂志 | 2016年 / 40卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Radiation, ionizing; Accident; Chromosome aberration; Lessons;
D O I：
暂无
中图分类号：
R818 [放射病、放射损伤];
学科分类号：
1001 ; 100105 ; 100207 ; 100602 ;
摘要：
Biomarkers,such as chromosome aberration and micronuclei assays,prove to be reliable for facilitating clinical diagnosis in radiation accidents.In a radiation accident in India,chromosomal aberration,γ-H2 AX,as well as other blood markers,were detected in accidentally exposed victims.This multi-parametric approach aided in confirming that individuals had been exposed by ionizing radiation.However,doses were impossible to estimate because of a 30-day delay in accident awareness.Exposure dose for victims was estimated using a dose-response curve previously established.Dose estimation,blood cell depletion kinetics,and no appearance of prodromal symptoms suggested that doses of exposure were low.Hematologic investigation,sampling time,and chromosome aberration scoring were all proposed according to data from the victims exposed to;Co.Finally,knowledge regarding chromosome aberration analysis and the importance of international co-operation and assistance should be shared from this accident.
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收藏
页码：128 / 132
页数：5
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