INHIBITION OF THE MYD88 PATHWAY BY CURCUMIN, THE ACTIVE CONSTITUENT OF TURMERIC(CURCUMA LONGA L.), CAUSES APOPTOSIS IN HEPATIC STELLATE CELLS(HSCS)

被引：0

作者：

Shu J

Kuchta K

He Y

Deng Y

Lin Y

Ye G

Lv X

Liu X

Kobayashi Y

机构：

[1] Department of Gastroenterology, Guangzhou Red Cross Hospital, Jinan University

[2] National Institute of Health Sciences, Division of Pharmacognosy

[3] Medical Corporation Soujikai

[4] Faculty of Medicine, Shimane University

来源：

World Journal of Traditional Chinese Medicine | 2015年 / 04期

关键词：

siRNA;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

1008 ;

摘要：

HSCs were divided into four groups,namely control group(A),MyD88 siRNA group(B),curcumin group(C),and curcumin+MyD88 siRNA group(D).Groups B and D were subjected to transient transfection with siRNA for 48h.Groups C and D were incubated with curcumin(25μmol/L)for 24h.MyD88 protein expression was observed by Western Blot,apoptosis was detected by flow cytometry,

引用

页码：93 / 94

页数：2

共 12 条

[1] Curcumin induces apoptosis in hepatic stellate cells via inhibition of the MyD88 pathway
Shu, J. C.
Kuchta, K.
He, Y. J.
Deng, Y. M.
Lin, Y.
Ye, G. R.
Lv, X.
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PLANTA MEDICA, 2015, 81 (16) : 1511 - 1511
[2] Curcumin, the main active constituent of turmeric (Curcuma longa L.), induces apoptosis in hepatic stellate cells by modulating the abundance of apoptosis-related growth factors
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[3] Curcumin Promotes Apoptosis of Activated Hepatic Stellate Cells by Inhibiting Protein Expression of the MyD88 Pathway
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[7] Regulation of Nur77-TLR4/MyD88 signaling pathway is required for Ginsenoside Rc ameliorates hepatic fibrosis regression by deactivating hepatic stellate cells
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