The role of sphingosine-1-phosphate in bone remodeling and osteoporosis

被引:10
|
作者
Justus M.Grewe [1 ,2 ]
Paul-Richard Knapstein [1 ]
Antonia Donat [1 ]
Shan Jiang [1 ]
Daniel J.Smit [3 ]
Weixin Xie [1 ]
Johannes Keller [1 ]
机构
[1] Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf
[2] Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf
[3] Clinic and Polyclinic for Vascular Medicine,University Heart Center Hamburg-Eppendorf
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中图分类号
R580 [];
学科分类号
1002 ; 100201 ;
摘要
Osteoporosis is a systemic bone disease that affects more than 200 million people worldwide and is caused by the disruption of the equilibrium between osteoclastic bone resorption and osteoblastic bone formation. Sphingosine-1-phosphate(S1 P) is a natural,bioactive sphingolipid that has been shown to play a major role in cardiovascular and immunological pathologies by regulating biological and cellular processes, including migration, differentiation, proliferation and survival. Recent studies also suggest a central role for S1 P in bone diseases, including osteoporosis; however, the effects of S1 P, particularly in bone metabolism, remain to be further elucidated. In this review, we summarize the available literature on the role of S1 P in bone metabolism with a focus on osteoporosis. On the cellular level, S1 P acts as an osteoclast-osteoblast coupling factor to promote osteoblast proliferation and bone formation. Moreover, the recruitment of osteoclast precursors to resorption sites is regulated by the interplay of S1 P gradients and S1 P receptor expression. From a clinical perspective, increasing evidence suggests that systemically elevated S1 P blood levels may serve as an independent risk factor for osteoporosis-related fractures. Taken together, S1 P signaling is a potential therapeutic target and may serve as a novel biomarker in patients with systemic bone disease.
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页码:265 / 273
页数:9
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