Gadd45a的表达调控与功能

被引：4
|
作者：
李云峰
钱海利
林晨
机构：
[1] 中国医学科学院肿瘤研究所分子肿瘤学国家重点实验室
来源：
医学分子生物学杂志 | 2007年 / 05期
关键词：
Gadd45a; DNA损伤; 细胞周期监控点; 细胞凋亡; 肿瘤;
D O I：
暂无
中图分类号：
R730.2 [肿瘤病理学、病因学];
学科分类号：
摘要：
哺乳动物细胞对于遗传毒性的刺激会产生一系列应答,如细胞周期阻滞,DNA修复和细胞凋亡等。Gadd45a在DNA损伤诱导的细胞应答中发挥重要作用。细胞内外环境的多种因素在转录水平、转录后水平、翻译后水平等多个层次对Gadd45a进行精确调节。Gadd45a通过与Cdc2相互作用调控细胞周期G2-M检测点,直接抑制Aurora-A激酶参与中心体稳定性的调节,通过G1-S期调控参与维持基因组的稳定性。Gadd45a参与p38/JNK、MAPK、线粒体介导的凋亡途径和NF-κB介导的生存通路调控。
引用
收藏
页码：434 / 438
页数：5
相关论文
共 9 条
  • [1] Posttranscriptional derepression of GADD45α by genotoxic stress
    Lal, A
    Abdelmohsen, K
    Pullmann, R
    Kawai, T
    Galban, S
    Yang, XL
    Brewer, G
    Gorospe, M
    [J]. MOLECULAR CELL, 2006, 22 (01) : 117 - 128
  • [2] Quercetin induces gadd45 expression through a p53-independent pathway
    Yoshida, T
    Maeda, A
    Horinaka, M
    Shiraishi, T
    Nakata, S
    Wakada, M
    Yogosawa, S
    Sakai, T
    [J]. ONCOLOGY REPORTS, 2005, 14 (05) : 1299 - 1303
  • [3] Genomic instability in Gadd45a-/- cells is coupled with S-phase checkpoint defects
    Hollander, MC
    Philburn, RT
    Patterson, AD
    Wyatt, MA
    Fornace, AJ
    [J]. CELL CYCLE, 2005, 4 (05) : 704 - 709
  • [4] Clinicopathological significance of GADD45 gene alterations in human familial breast carcinoma
    Sensi, E
    Tancredi, M
    Aretini, P
    Cipollini, G
    Collecchi, P
    Naccarato, AG
    Viacava, P
    Bevilacqua, G
    Caligo, MA
    [J]. BREAST CANCER RESEARCH AND TREATMENT, 2004, 87 (02) : 197 - 201
  • [5] Involvement of the MAP kinase pathways in induction of GADD45 following UV radiation
    Tong, T
    Fan, WH
    Zhao, HC
    Jin, SQ
    Fan, FY
    Blanck, P
    Alomo, I
    Rajasekaran, B
    Liu, YS
    Holbrook, NJ
    Zhan, QM
    [J]. EXPERIMENTAL CELL RESEARCH, 2001, 269 (01) : 64 - 72
  • [6] The central region of Gadd45 is required for its interaction with p21/WAF1
    Zhao, HC
    Jin, SQ
    Antinore, MJ
    Lung, FDT
    Fan, FY
    Blanck, P
    Roller, P
    Fornace, AJ
    Zhan, QM
    [J]. EXPERIMENTAL CELL RESEARCH, 2000, 258 (01) : 92 - 100
  • [7] A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK
    Takekawa, M
    Saito, H
    [J]. CELL, 1998, 95 (04) : 521 - 530
  • [8] Abrogation of p53function affects gadd gene responses to DNAbase-damaging agents and star-vation .2 ZHAN Q,FANS,SMITHML,et al. DNA Cell Biol . 1996
  • [9] GADD45 alpha is highly expressed in pancreatic ductal adenocarcinoma cells and required for tumor cell viability .2 Schneider G,Weber A,Zechner U,et al. Int J Cancer . 2006
1