SKP2、p27kip1与人类消化系统肿瘤的研究现状

[1] Hara T,Kamura T,Nakayama K,et al.Degradation of p27Kip1 at the G0-G1 transitionmediated by a SKP2-independent ubiquitination pathway. Journal of Biological Chemistry . 2001

[2] Eguchi H,Herschenhous N,Kuzushita N,et al.Helicobacter pylori increases proteasome-mediated degradation of p27 ( kip1 ) in gastric epithelial cells. Cancer Research . 2003

[3] Nakayama K,Nagahama H,Minamishima YA,et al.Targeted disruption of SKP2 results in accumulation of cyclin E and p27Kip1 , polyploidy and centrosome overduplication. EMBO Journal . 2000

[4] Nelsen CJ,Hansen LK,Rickheim DG,et al.Induction of hepatocyte proliferation and liver hyperplasia by the targeted expression of cyclin E and SKP2. Proceedings of the National Academy of Sciences of the United States of America . 2001

[5] Ezoe S,Matsumura I,Nakata S,et al.GATA-2/estrogen receptor chimera regulates cytokine-dependent growth of hematopoietic cells through accumulation of p21 (WAF1 )and p27(Kip1) proteins. Blood . 2002

[6] Masuda TA,Inoue H,Sonoda H,et al.Clinical and biological significance of S-phase kinase-associated protein 2(SKP2) gene expression in gastric carcinoma: modulation of malignant phenotype by SKP2 overexpression, possibly via p27 proteolysis. Cancer Research . 2002

[7] Latres E,Chiarle R,Schulman BA,et al.Role of the Fbox protein SKP2 in lymphomagenesis. Proceedings of the National Academy of Sciences of the United States of America . 2001

[8] Fukuchi M,Masuda N,Nakajima M,et al.Inverse correlation between expression levels of p27 and the ubiquitin ligase subunit SKP2 in early esophageal squamous cell carcinoma. Anticancer Research . 2004

[9] Spruck C,Strohmaier H,Watson M,et al.A CDK-independent function of mammalian Cks1: targeting of SCF(SKP2) to the CDK inhibitor p27kip1. Molecular Cell . 2001

[10] Farhana L,Dawson M,Rishi AK,et al.CyclinB and E2 F-1 expression in prostate carcinoma cells treated with the novel retinoid CD437 are regulated by the ubiquitinmediated pathway. Cancer Research . 2002

[1] Hara T,Kamura T,Nakayama K,et al.Degradation of p27Kip1 at the G0-G1 transitionmediated by a SKP2-independent ubiquitination pathway. Journal of Biological Chemistry . 2001

[2] Eguchi H,Herschenhous N,Kuzushita N,et al.Helicobacter pylori increases proteasome-mediated degradation of p27 ( kip1 ) in gastric epithelial cells. Cancer Research . 2003

[3] Nakayama K,Nagahama H,Minamishima YA,et al.Targeted disruption of SKP2 results in accumulation of cyclin E and p27Kip1 , polyploidy and centrosome overduplication. EMBO Journal . 2000

[4] Nelsen CJ,Hansen LK,Rickheim DG,et al.Induction of hepatocyte proliferation and liver hyperplasia by the targeted expression of cyclin E and SKP2. Proceedings of the National Academy of Sciences of the United States of America . 2001

[5] Ezoe S,Matsumura I,Nakata S,et al.GATA-2/estrogen receptor chimera regulates cytokine-dependent growth of hematopoietic cells through accumulation of p21 (WAF1 )and p27(Kip1) proteins. Blood . 2002

[6] Masuda TA,Inoue H,Sonoda H,et al.Clinical and biological significance of S-phase kinase-associated protein 2(SKP2) gene expression in gastric carcinoma: modulation of malignant phenotype by SKP2 overexpression, possibly via p27 proteolysis. Cancer Research . 2002

[7] Latres E,Chiarle R,Schulman BA,et al.Role of the Fbox protein SKP2 in lymphomagenesis. Proceedings of the National Academy of Sciences of the United States of America . 2001

[8] Fukuchi M,Masuda N,Nakajima M,et al.Inverse correlation between expression levels of p27 and the ubiquitin ligase subunit SKP2 in early esophageal squamous cell carcinoma. Anticancer Research . 2004

[9] Spruck C,Strohmaier H,Watson M,et al.A CDK-independent function of mammalian Cks1: targeting of SCF(SKP2) to the CDK inhibitor p27kip1. Molecular Cell . 2001

[10] Farhana L,Dawson M,Rishi AK,et al.CyclinB and E2 F-1 expression in prostate carcinoma cells treated with the novel retinoid CD437 are regulated by the ubiquitinmediated pathway. Cancer Research . 2002