Preimplantation genetic diagnosis for Down syndrome pregnancy

被引:0
|
作者
ZHANG Yu
机构
关键词
Down syndrome; Fluorescence in site hybridization (FISH); Preimplantation genetic diagnosis (PGD);
D O I
暂无
中图分类号
R715 [临床优生学];
学科分类号
1004 ;
摘要
Objective: To evaluate the effect of preimplantation genetic diagnosis (PGD) conducted for women who had Down syndrome pregnancy previously. Methods: Trisomy 21 was diagnosed by using fluorescence in site hybridization (FISH) before embryo transfer in two women who had Down syndrome pregnancies. Each received one or two PGD cycles respectively. Results: Case 1: one PGD cycle was conducted, two oocytes were fertilized and biopsied. One embryo is of trisomy 21 and the other of monosomy 21. No embryo was transferred. Case 2: two PGD cycles were conducted, in total, sixteen oocytes were fertilized and biopsied. Four embryos were tested to be normal, six of trisomy 21, and one of monosomy 21. Five had no signal. Four normal embryos were transferred but no pregnancy resulted. Conclusion: For couples who had pregnancies with Down syndrome pre-viously, PGD can be considered, and has been shown to be an effective strategy.
引用
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页码:515 / 521
页数:7
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