NAP1L1与肿瘤的关系及其研究进展

被引：1

作者：

谯钰琪 ^{[1
,2
]}

惠盼 ^{[1
,2
]}

南岩东 ^{[1
]}

机构：

[1] 空军军医大学唐都医院呼吸与危重症医学科

[2] 延安大学医学院

来源：

中华肺部疾病杂志(电子版) | 2021年 / 14卷 / 06期

关键词：

NAP1L1; 肿瘤; 生物标志物;

D O I：

暂无

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

摘要：

<正>肿瘤的高致死率严重增加着人类社会的健康负担,筛选合适的肿瘤标志物对于肿瘤的诊断、预测预后以及开发新疗法至关重要。核小体组装蛋白1样蛋白1 (nucleosome assembly protein 1-like 1,NAP1L1)是从人胸腺cDNA文库中分离得到的核小体组装蛋白1(nucleosome assembly protein1,NAP1)的同源物,继早期预测和探索出其核小体组装与重塑、调控细胞周期与转录等功能后,近年研究发现,它在多种肿瘤细胞系中表达异常,与肿瘤侵袭性与耐药相关,有望作为潜在的生物标志物和治疗靶点。本文对NAP1L1与肿瘤的关系及其研究进展进行综述。

引用

页码：827 / 829

页数：3

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