Effect of Scurrula atropurpurea on blood pressure and angiotensin Ⅱ of deoxycorticosterone acetate-salt hypertensive rats

OBJECTIVE To investigate the effect of methanolic extract of Scurrula atropurpurea on systolic blood pressure and serum angiotensinⅡ concentration in deoxycorticosterone acetate-salt(DOCA-salt)hypertensive rats.METHODS Twenty-five male Wistar rats were divided into normal control group and four hypertensive groups by DOCA-salt for 6 weeks.Further,three hypertensive groups were orally administered with methanolic extract of Scurrula atropurpurea at a doses of 50,100 and 200mg·kg-1,respectively for 6 weeks and one hypertensive group without extract as positive control.At the end of research systolic blood pressure were measured by tail cuff methods.Serum angiotensinⅡ were measured by ELISA.RESULTS The systolic blood pressure increased significantly in the positive control hypertensive group compared to the normal control group(P<0.05).Administration of methanolic extract of Scurrula atropurpurea 50,100 and 200mg·kg-1 significantly decreased systolic blood pressure,respectively compared to the positive control hypertensive group(P<0.05).There was no different angiotensinⅡ consentration between positive control hypertensive group and normal group,while methanolic extract of Scurrula atropurpurea 50mg·kg-1 caused decreased angiotensinⅡ conscentration significantly compared to positive control hypertensive group(P<0.05).CONCLUSION Methanolic extract of Scurrula atropurpurea produced antihypertensive effect and decreasing angiotensinⅡ concentration at 50mg·kg-1 in hypertensive rat.Beside this,the concentration of angiotensinⅡ couldn′t increase in DOCA-salt hypertensive rats.