Effects of dl-praeruptorin A on nucleus factor-κB and tumor necrosis factor-α expression in ischemia-reperfusion hearts

被引：0
|
作者：
Chi WANG
机构：
来源：
Acta Pharmacologica Sinica | 2004年 / 01期
关键词：
<Keyword>dl-praeruptorin A; myocardial; ischemia; reperfusion injury; nucleus factor-κB; tumor necrosis factor-α;
D O I：
暂无
中图分类号：
R965 [实验药理学];
学科分类号：
100602 ; 100706 ;
摘要：
AIM: To study the effects of dl-praeruptorin A (Pd-Ia) on nucleus factor-κB (NF-κB) activativity and tumor necrosis factor-α(TNF-α)expression in ischemia-reperfusion (I/R) myocardium. METHODS: Langendorff’s isolated rat heart was subjected to a 10-min ischemia followed by a 30-min reperfusion. NF-κB activity in nucleus was analyzed by Sandwich Enzyme-Linked Immunosorbent Assay (ELISA). TNF-α level in cytoplasm was measured by
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页码：37 / 42
页数：6
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