iGluR expression in the hippocampal formation,entorhinal cortex,and superior temporal gyrus in Alzheimer's disease

Alzheimer’s disease(AD) constitutes the largest proportion of dementia worldwide,with a significant associated medical burden.The major pathological hallmarks of AD include the gradual accumulation and deposition of amyloid-beta(Aβ) plaques and hyperphosphorylated tau protein(Revett et al.,2013).Whilst investigations centered around the tau and Aβ hypothesis have been the main focus for the previous decades,the lack of therapeutic solutions has pushed for research into other potential therapeutic targets.Pathological alterations in the glutamatergic system have been postulated to play a central role in the pathogenesis of AD,with intimate downstream and upstream interactions with both Aβ and tau protein(Revett et al.,2013;Yeung et al., 2020 a,b;Kwakowsky et al.,2021).