粉末冶金制备的多孔Ti-10Mo合金用于促进骨修复的研究（英文）

被引：0

作者：

徐伟 ^{[1
,2
]}

刘卓 ^{[3
]}

路新 ^{[1
,2
]}

田静静 ^{[3
]}

陈刚 ^{[1
,2
]}

刘博文 ^{[1
,2
]}

李舟 ^{[3
]}

曲选辉 ^{[1
,2
]}

文翠娥 ^{[4
]}

机构：

[1] Beijing Advanced Innovation Center for Materials Genome Engineering, University of Science and Technology Beijing

[2] Beijing Advanced Innovation Center for Materials Genome Engineering, Institute for Advanced Materials and Technology, University of Science and Technology Beijing

[3] CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences

[4] School of Engineering, RMIT University

来源：

Science China Materials | 2019年 / 62卷 / 07期

基金：

英国医学研究理事会; 中央高校基本科研业务费专项资金资助;

关键词：

porosity; powder metallurgy; structure characterization; cell cytotoxicity; osteointegration;

D O I：

暂无

中图分类号：

TF125.6 []; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

本文中,我们以元素粉末为原料,采用粉末冶金造孔剂法制备了多孔Ti-10Mo合金,系统探讨了所制备的多孔Ti-10Mo合金的孔隙特征、显微组织、力学性能、体外生物相容性及体内骨整合能力.结果表明,随着造孔剂含量的增加(碳酸氢铵),在1300°C下烧结的多孔Ti-10Mo合金均由魏氏体组织组成.所制备的Ti-10Mo合金的孔隙率与平均孔尺寸能够分别控制在50.8%–66.9%与70.1–381.4μm.孔隙率为63.4%的Ti-10Mo合金具有最适合植入应用的力学性能,其弹性模量为2.9 GPa,抗压屈服强度为127.5 MPa.在体外, Ti-10Mo合金浸提液对细胞增殖没有不良影响.细胞在浸提液中的存活率高于对照组,表明合金无毒性并且具有良好的生物学特征.在体内,植入8周后合金周围被新生骨包围,并且植入部分未见明显炎症.随着植入时间由2周增加到8周,多孔Ti-10Mo合金的骨结合强度从46.6 N增加到176.4 N.适合的力学性能以及良好的体外生物相容性和体内骨整合性使粉末冶金法制备的多孔Ti-10Mo成为一种具有吸引力的骨科植入合金.

引用

页码：1053 / 1064

页数：12

共 41 条

[1] 钛合金多孔植入物:骨整合、血管化和临床实验（英文）
李述军
李小康
侯文韬
Krishna C.Nune
R.Devesh K.Misra
Victor L.Correa-Rodriguez
郭征
郝玉琳
杨锐
Lawrence E.Murr
[J]. Science China Materials, 2018, 61 (04) : 525 - 536
[2] 电子束增材制造医用钛合金三维多孔支架力学及生物功能研究进展（英文）
Krishna Chaitanya Nune
李述军
R.Devesh Kumar Misra
[J]. Science China Materials, 2018, 61 (04) : 455 - 474
[3] 用于矫形外科的增材制造金属植入物（英文）
Kwok-Chuen Wong
Peter Scheinemann
[J]. Science China Materials, 2018, 61 (04) : 440 - 454
[4] Vascularization in interconnected 3D printed Ti-6Al-4V foams with hydrogel matrix for biomedical bone replacement implants.[J].Victor L.Correa;Kristine M.Garza;Lawrence E.Murr;.Science China Materials.2018, 04
[5] 可降解、可吸收、再吸收——哪个是描述最终被人体吸收生物材料的最好词汇?（英文）
刘洋
郑玉峰
拜伦海耶斯
[J]. Science China Materials, 2017, 60 (05) : 377 - 391
[6] Mechanical properties, in vitro corrosion resistance and biocompatibility of metal injection molded Ti-12Mo alloy for dental applications.[J].W. Xu;X. Lu;L.N. Wang;Z.M. Shi;S.M. Lv;M. Qian;X.H. Qu.Journal of the Mechanical Behavior of Biomedical Materials.2018,
[7] Topological design and additive manufacturing of porous metals for bone scaffolds and orthopaedic implants: A review.[J].Xiaojian Wang;Shanqing Xu;Shiwei Zhou;Wei Xu;Martin Leary;Peter Choong;M. Qian;Milan Brandt;Yi Min Xie.Biomaterials.2016,
[8] Influence of pore size of porous titanium fabricated by vacuum diffusion bonding of titanium meshes on cell penetration and bone ingrowth.[J].Bei Chang;Wen Song;Tianxiao Han;Jun Yan;Fuping Li;Lingzhou Zhao;Hongchao Kou;Yumei Zhang.Acta Biomaterialia.2016,
[9] Selective laser sintered porous Ti–(4–10)Mo alloys for biomedical applications: Structural characteristics, mechanical properties and corrosion behaviour.[J].Fangxia Xie;Xueming He;Yanming Lv;Meiping Wu;Xinbo He;Xuanhui Qu.Corrosion Science.2015,
[10] Mechanical properties and in vitro biological response to porous titanium alloys prepared for use in intervertebral implants.[J].C. Caparrós;J. Guillem-Martí;M. Molmeneu;M. Punset;J.A. Calero;F.J. Gil.Journal of the Mechanical Behavior of Biomedical Materials.2014,

← 1 2 3 4 5 →