Diagnostic sensitivity of imaging modalities for hepatocellular carcinoma smaller than 2 cm

被引:0
|
作者
Keiji Mita [1 ]
Soo Ryang Kim [1 ]
Masatoshi Kudo [2 ]
Susumu Imoto [1 ]
Taisuke Nakajima [1 ]
Kenji Ando [1 ]
Katsumi Fukuda [1 ]
Toshiyuki Matsuoka [3 ]
Yoko Maekawa [4 ]
Yoshitake Hayashi [5 ]
机构
[1] Department of Gastroenterology,Kobe Asahi Hospital
[2] Department of Gastroenterology and Hepatology,Kinki University School of Medicine
[3] Department of Radiology,Osaka City University Medical School
[4] Department of Surgery,Hyogo Cancer Center
[5] Center for Infectious Diseases,Kobe University Graduate School of Medicine
关键词
Computed tomography arterioportal angi- ography; Contrast-enhanced computed tomography; Diagnostic sensitivity; Gd-EOB-DTPA-enhanced magnetic resonance imaging; Hepatocellular carcinoma smaller than 2 cm:Sonazoid contrast-enhanced ultrasonography;
D O I
暂无
中图分类号
R735.7 [肝肿瘤];
学科分类号
100214 ;
摘要
AIM:To compare the imaging results with histology and to evaluate the diagnostic sensitivity of imaging modalities for hepatocellular carcinoma(HCC)smaller than 2 cm.METHODS:Nodules smaller than 2 cm(n=34)revealed by ultrasonography(US)in 29 patients with liver cirrhosis were analyzed.Histological diagnosis of HCC was performed by ultrasonographic guidance:moderately-differentiated HCC(n=24);well-differentiated HCC(n=10).The patterns disclosed by the four imaging modalities defined the conclusive diagnosis of HCC:(1)contrast-enhanced computed tomography(CECT),hypervascularity in the arterial phase and washout in the equilibrium phase;(2)Sonazoid contrast-enhanced US(CEUS),hypervascularity in the early vascular phase and defect in the Kupffer phase;(3)gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid(Gd-EOBDTPA)-enhanced magnetic resonance imaging(MRI),hypervascularity in the arterial phase and/or defect in the hepatobiliary phase;and(4)CT arterioportal angiography:hypervascularity by CT during arteriography and/ or perfusion defect by CT during arterial portography.RESULTS:Overall,the sensitivity of diagnosing HCC smaller than 2 cm was 52.9%(18/34)(95%CI:35.170.2)by CECT;67.6%(23/34)(95%CI:49.5-82.6)by Sonazoid CEUS;76.5%(26/34)(95%CI:58.8-89.3) by Gd-EOB-DTPA MRI;and 88.2%(30/34)(95%CI: 72.5-96.7)by CT arterioportal angiography.The diagnostic sensitivity of detecting moderately-differentiated HCC by CECT,Sonazoid CEUS,Gd-EOB-DTPA MRI and CT arterioportal angiography was 62.5%(15/24)(95%CI: 40.6-81.2),79.2%(19/24)(95%CI:57.8-92.9),75.0% (18/24)(95%CI:53.3-90.2)and 95.8%(23/24)(95% CI:78.9-99.9),respectively.A significant difference(P< 0.05)was observed between CECT and CT arterioportal angiography in all nodules.There was no difference between Sonazoid CEUS,Gd-EOB-DTPA MRI,and CT arterioportal angiography.The combined sensitivity of Sonazoid CEUS and Gd-EOB-DTPA MRI was 94.1%(32/34).CONCLUSION:Changing the main diagnostic modality for HCC smaller than 2 cm from CT arterioportal angiography to Sonazoid CEUS and Gd-EOB-DTPA MRI is recommended.
引用
收藏
页码:4187 / 4192
页数:6
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