KIF6基因rs20455多态性与中国北方汉族人冠心病及血脂水平的关联研究

被引：6

作者：

许文燊 ^{[1
]}

鄢盛恺 ^{[1
]}

杨辉 ^{[1
]}

夏良裕 ^{[2
]}

机构：

[1] 卫生部中日友好医院检验科

[2] 中国医学科学院北京协和医学院北京协和医院检验科

来源：

中国分子心脏病学杂志 | 2011年 / 11卷 / 06期

关键词：

冠心病; 驱动蛋白分子6; 多态性;

D O I：

10.16563/j.cnki.1671-6272.2011.06.009

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

摘要：

目的分析KIF6基因rs20455多态性与中国北方汉族人群冠心病及血脂水平的关系。方法收集164例冠心病(CHD)患者及152例健康人的外周血标本;应用聚合酶链反应-限制性片段长度多态性技术检测KIF6 rs20455多态性;研究基因多态性对血糖、血脂水平的可能影响。结果中国北方汉族人KIF6基因rs20455多态性位点TT、TC、CC基因型频率分别为0.291,0.491与0.218;T等位基因,C等位基因频率分别为0.536与0.464。基因型和等位基因频率在组间分布差异均无统计学意义(P>0.05)。本研究对象rs20455多态性基因型和等位基因频率分布与高加索,非裔美洲人群有统计学差异(P<0.001)。rs20455基因多态性与血糖、血脂水平、性别、年龄、高血压病史无显著性关联。Logistic回归显示,年龄、TG、HbAlc是本组研究对象发生冠心病的主要危险因素(OR分别为1.178、26.18、17.415,P<0.05)。C等位基因不是发生冠心病的独立危险因素。结论未发现KIF6基因rs20455多态性与本研究人群的冠心病发生及血脂水平存在明显关联性。

引用

页码：350 / 354

页数：5

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