PREPARATION AND CHARACTERIZATION OF DOXORUBICIN-LOADED MAGNETIC ANTICANCER NANOPARTICLES

被引：0
|
作者：
LV Fengjiao1 LIN Huaxiang2 CHEN Xiaogeng3 XU Xiaoping2 1. School of Chemistry and life sciences
2. School of Chemistry and Chemical Engineering
机构：
来源：
Chinese Journal of Reactive Polymers | 2007年 / Z1期
关键词：
Magnetic nanoparticles; Polyvinylpyrrolidone; Inverse emulsion polymerization;
D O I：
暂无
中图分类号：
R94 [药剂学];
学科分类号：
100602 ; 100702 ;
摘要：
Doxorubicin(ADM)-loaded magnetic anticancer nanoparticles,using Fe3O4 as core, doxorubicin as model drug and polyvinylpyrrolidone (PVP) as matrix, were prepared by inverse emulsion polymerization. The experimental results showed that the average diameter of Fe3O4 particles was 19.8nm. The X-ray diffraction indicated that the prepared Fe3O4 particle was pure cubic Fe3O4. The results obtained by SEM showed the magnetic nanoparticles under optimal operating condition had a smooth spherical surface , LLS showed an average size of 78.7nm. And IR results demonstrated that they consisted of ADM, PVP and Fe3O4.
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页码：96 / 100
页数：5
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