PC-002 (Sepantronium Bromide) Enhances the Antitumor Efficacy of Anti-CD20 Antibody By CD20 Upregulation

被引：0
|
作者：
Jiang, Vernon [1 ]
Li, Xiang [1 ]
He, Na [1 ]
Lv, Yan [1 ]
Wang, Haiyue [1 ]
Zhang, Ming [1 ]
Zhai, Heiyan [1 ]
Yang, Zhen [1 ]
Yang, Yi [1 ]
Guo, Dagang [1 ]
Cao, Zhixiang [1 ]
Chen, Yiyou [1 ]
机构：
[1] Cothera Biosci, San Mateo, CA USA
来源：
BLOOD | 2024年 / 144卷
关键词：
D O I：
10.1182/blood-2024-209648
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：5822 / 5823
页数：2
相关论文
共 50 条
  • [1] Measuring CD20 binding for humanization of anti-CD20 antibody
    Meng, YJG
    Hong, K
    Presta, L
    Penn, A
    Adams, C
    Chuntharapai, A
    Yang, JH
    Lu, YM
    Wong, WL
    FASEB JOURNAL, 2004, 18 (04): : A59 - A59
  • [2] MODULATION OF CD20 EXPRESSION ON B CELLS BY ANTI-CD20 ANTIBODIES
    Bellintani, Elaine C.
    de Marco, Renato
    Fantini, Renata
    Valim, Tiago
    Macedo, Denise
    Miyamoto, Yuriko
    Temin, Julia
    Gerbase-DeLima, Maria
    HUMAN IMMUNOLOGY, 2016, 77 : 138 - 138
  • [3] INFLUENCE OF HISTONE DEACETYLASE INHIBITORS (HDACI) ON CD20 EXPRESSION AND EFFICACY OF ANTI-CD20 MONOCLONAL ANTIBODIES
    Wanczyk, M.
    Kozikowski, M.
    Dwojak, M.
    Bojarczuk, K.
    Winiarska, M.
    HAEMATOLOGICA, 2013, 98 : 409 - 409
  • [4] Unexpected and persistent depletion of B lymphocytes CD20 following a minimum dose of anti-CD20 antibody (Rituximab)
    Bruzzese, V.
    Pepe, J.
    REUMATISMO, 2009, 61 (04) : 306 - 308
  • [5] Rituxan (anti-CD20 antibody)-induced translocation of CD20 into lipid rafts is crucial for calcium influx and apoptosis
    Janas, E
    Priest, R
    Wilde, JI
    White, JH
    Malhotra, R
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2005, 139 (03): : 439 - 446
  • [6] Loss of CD20 expression following treatment with anti-CD20 monoclonal antibody in chronic lymphocytic leukemia.
    Savage, KJ
    Weng, AP
    Kutok, JL
    Pinkus, G
    Gribben, JG
    BLOOD, 2002, 100 (11) : 364B - 364B
  • [7] HDAC6 inhibition upregulates CD20 levels and increases the efficacy of anti-CD20 monoclonal antibodies
    Bobrowicz, Malgorzata
    Dwojak, Michal
    Pyrzynska, Beata
    Stachura, Joanna
    Muchowicz, Angelika
    Berthel, Elise
    Dalla-Venezia, Nicole
    Kozikowski, Mieszko
    Siernicka, Marta
    Miazek, Nina
    Zapala, Piotr
    Domagala, Antoni
    Bojarczuk, Kamil
    Malenda, Agata
    Barankiewicz, Joanna
    Graczyk-Jarzynka, Agnieszka
    Zagozdzon, Agnieszka
    Gabrysiak, Magdalena
    Diaz, Jean-Jacques
    Karp, Marta
    Lech-Maranda, Ewa
    Firczuk, Malgorzata
    Giannopoulos, Krzysztof
    Efremov, Dimitar G.
    Laurenti, Luca
    Baatout, Dunja
    Frenzel, Lukas
    Malinowska, Agata
    Slabicki, Mikolaj
    Zenz, Thorsten
    Zerrouqi, Abdessamad
    Golab, Jakub
    Winiarska, Magdalena
    BLOOD, 2017, 130 (14) : 1628 - 1638
  • [8] HDAC6 Inhibition Increases Translation of CD20 mRNA and Potentiates the Efficacy of Anti-CD20 Immunotherapy
    Bobrowicz, Malgorzata
    Stachura, Joanna
    Dwojak, Michal
    Domagala, Antoni
    Pyrzynska, Beata
    Berthel, Elise
    Venezia, Nicole Dalla
    Siernicka, Marta
    Firczuk, Malgorzata
    Winiarska, Magdalena
    BLOOD, 2016, 128 (22)
  • [9] CD20 negative, small lymphocytic lymphoma (SLL) following anti-CD20 monoclonal antibody therapy: An autopsy study
    Overstreet, K
    Weidner, N
    Masliah, E
    Herndier, B
    MODERN PATHOLOGY, 2002, 15 (01) : 7A - 7A
  • [10] CD20 negative, small lymphocytic lymphoma (SLL) following anti-CD20 monoclonal antibody therapy: An autopsy study
    Overstreet, K
    Weidner, N
    Masliah, E
    Herndier, B
    LABORATORY INVESTIGATION, 2002, 82 (01) : 7A - 7A
12345