Predicting various types of intermolecular interactions and the strength of the bond between the solute and solvent using thermos-acoustical and volumetric data is highly useful. Salts and amino acids are two types of nutrients that are plentiful in the human body. Several properties of histidine+H2O and histidine+H2O+K2SO4 systems, both volumetric and thermos-acoustical, have been investigated in this work. Thermodynamic L-histidine (C6H9N3O2) studies have been conducted in an ionic salt (K2SO4) solution at two different temperatures. C(6)H(9)N(3)O(2 )has been examined at several mass fraction ranges in water and aqueous potassium salt solution (K2SO4), with ultrasonic velocities and densities of 0.1 mol/kg (i.e., 0.02 - 0.2 mol/kg). Utilizing ultrasonic velocity and density data, various thermos-acoustical features have been identified, including surface tension, adiabatic compressibility, non-linearity parameter, specific heat ratio, relaxation strength, and acoustic impedance. A study has been carried out to investigate the physicochemical behavior and nature of the interaction of L-Histidine in potassium salt (K2SO4) water-based solutions at two different temperatures (283 and 293 K). Numerous intermolecular interactions between various component mixes at various mass fractions have been interpreted in the current investigation of the binary system (potassium sulphate + histidine). Based on the whole scenario, we can also infer that higher mass fractions at higher temperatures are associated with greater interactions between the solute and solvent. Consequently, figuring out the medium's physical and chemical properties (as depicted in Fig. a) can be accomplished by measuring the ultrasonic velocity in the designated media.
