Single-cell RNA sequencing identifies the fundamental role of intrahepatic CD8+T cells in the pathogenesis of autoimmune hepatitis

被引:0
|
作者
Olivas, Ignasi [1 ,2 ]
Rill, Aina
Koutsoudakis, Georgios [2 ]
Roldan, Yasmin [2 ]
Arvaniti, Pinelopi [1 ,2 ,4 ]
Rodriguez-Tajes, Sergio [1 ,2 ,5 ]
Lens, Sabela [1 ,2 ,5 ]
Mereu, Elisabetta [3 ]
Carlota Londono, Maria [1 ,2 ,5 ]
机构
[1] Hosp Clin Barcelona, Liver Unit, Barcelona, Spain
[2] Inst Invest Biomed August Pi y Sunyer IDIBAPS, Barcelona, Spain
[3] Inst Invest Leucemia Josep Carreras IJC, Badalona, Spain
[4] Univ Hosp Larissa, Dept Med & Res Lab Internal Med, Expertise Ctr Greece Autoimmune Liver Dis, ERN RARE LIVER, Larisa, Greece
[5] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain
关键词
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
SAT-153-YI
引用
收藏
页码:S293 / S294
页数:2
相关论文
共 50 条
  • [1] Single-cell RNA sequencing of CD8+T cells to prioritize immunotherapy combinations
    Shrestha, Yashaswi
    Kuziora, Michael
    Greenlees, Lydia
    Higgs, Brandon
    Streicher, Katie
    Raja, Rajiv
    Ranade, Koustubh
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2017, 5
  • [2] Autoimmune CD8+T cells in type 1 diabetes: from single-cell RNA sequencing to T-cell receptor redirection
    Yang, Kangping
    Zhang, Yihan
    Ding, Jiatong
    Li, Zelin
    Zhang, Hejin
    Zou, Fang
    FRONTIERS IN ENDOCRINOLOGY, 2024, 15
  • [3] Single-Cell Sequencing Identifies the Heterogeneity of CD8+T Cells and Novel Biomarker Genes in Hepatocellular Carcinoma
    Wang, Hailei
    Fu, Yang
    Da, Bin-Bin
    Xiong, Geng
    JOURNAL OF HEALTHCARE ENGINEERING, 2022, 2022
  • [4] Single-cell RNA sequencing unveils metabolic and transcriptional dynamics in CD8+T cells of Autoimmune Hepatitis murine model, offering insights into potential therapeutic targets
    Dolasia, Komal
    Centa, Monica
    Giotti, Bruno
    Ughetta, Mimi
    Alexandropoulos, Konstantina
    Tsankov, Alexander
    JOURNAL OF IMMUNOLOGY, 2024, 212 (01):
  • [5] Astaxanthin Alleviates Autoimmune Hepatitis by Modulating CD8+ T Cells: Insights From Mass Cytometry and Single-Cell RNA Sequencing Analyses
    He, Yuting
    Ding, Mingjie
    Zhang, Jiakai
    Huang, Changjun
    Shi, Jihua
    Wang, Yun
    Tao, Ruolin
    Wu, Zeyu
    Guo, Wenzhi
    ADVANCED SCIENCE, 2024, 11 (30)
  • [6] Deciphering the role of CD8+T cells in IBD: from single-cell analysis to biomarkers
    Ray, Katrina
    NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2020, 17 (10) : 595 - 595
  • [7] Single-cell RNA sequencing of autoimmune hepatitis identifies pathogenic marker MIF and reveals distinctions between CD8-Tc-PDCD1 cells in autoimmunity and cancer
    Cai, Chao
    Liu, Chenyi
    Li, Shu
    Chen, Chen
    Cai, Yijing
    Chen, Lu
    Zhang, Huifang
    Zhou, Bangguo
    Lu, Mingqin
    JOURNAL OF HEPATOLOGY, 2024, 80 : S333 - S334
  • [8] Development of single-cell ROS regulome profiles of CD8+T cells
    Wang, Yi-chuan
    JOURNAL OF IMMUNOLOGY, 2024, 212 (01):
  • [9] Single-cell atlas of colonic CD8+T cells in ulcerative colitis
    Corridoni, Daniele
    Antanaviciute, Agne
    Gupta, Tarun
    Fawkner-Corbett, David
    Aulicino, Anna
    Jagielowicz, Marta
    Parikh, Kaushal
    Repapi, Emmanouela
    Taylor, Steve
    Ishikawa, Dai
    Hatano, Ryo
    Yamada, Taketo
    Xin, Wei
    Slawinski, Hubert
    Bowden, Rory
    Napolitani, Giorgio
    Brain, Oliver
    Morimoto, Chikao
    Koohy, Hashem
    Simmons, Alison
    NATURE MEDICINE, 2020, 26 (09) : 1480 - 1490
  • [10] A single-cell approach to engineer CD8+T cells targeting cytomegalovirus
    Wang, Fei
    Xu, Qumiao
    Zhuang, Zhenkun
    Li, Ziyi
    Gao, Qianqian
    Huang, Yaling
    Luo, Yonglun
    Zhang, Xiuqing
    Zhu, Linnan
    Chao, Cheng-chi
    CELLULAR & MOLECULAR IMMUNOLOGY, 2021, 18 (05) : 1326 - 1328