TP53 genetic heterogeneity in recurrent or second primary head and neck squamous cell carcinoma

被引：0

作者：

Kampel, Liyona ^{[1
,2
,4
]}

Feldstein, Sara ^{[3
,4
]}

Tsuriel, Shlomo ^{[3
,4
]}

Trejo, Leonor Leider ^{[3
,4
]}

Horowitz, Gilad ^{[2
,4
]}

Warshavsky, Anton ^{[2
,4
]}

Mansour, Jobran ^{[2
,4
]}

Hershkovitz, Dov ^{[3
,4
]}

Muhanna, Nidal ^{[1
,2
,4
]}

机构：

[1] Tel Aviv Sourasky Med Ctr, Head & Neck Canc Res Lab, Tel Aviv, Israel

[2] Tel Aviv Sourasky Med Ctr, Dept Otolaryngol Head & Neck Surg & Maxillofacial, Tel Aviv, Israel

[3] Tel Aviv Sourasky Med Ctr, Canc Res & Pathol Inst, Tel Aviv, Israel

[4] Tal Aviv Univ, Fac Med & Hlth Sci, Tel Aviv, Israel

来源：

RADIOTHERAPY AND ONCOLOGY | 2025年 / 204卷

关键词：

TP53; Head and neck squamous cell carcinoma; Recurrence; Irradiation; PROGRESSION MODEL; CANCER; CHEMORADIOTHERAPY; CHEMOTHERAPY;

D O I：

10.1016/j.radonc.2025.110714

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Head and neck squamous cell carcinomas (HNSCC) frequently recur, and patients often develop second primary tumors. Their distinction is clinically challenging. TP53 mutational heterogeneity may indicate novel molecular events rather than resistant clones' expansion or persistent disease. Surveillance and therapeutic strategies should be adjusted, especially in the case of a second primary arising in an already irradiated field.

引用

页数：5

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