The microbiome and acute organ injury: focus on kidneys

被引：1

作者：

Patel, Shishir Kumar ^{[1
]}

Gooya, Mahta ^{[1
]}

Guo, Qisen ^{[1
]}

Noel, Sanjeev ^{[1
]}

Rabb, Hamid ^{[1
]}

机构：

[1] Johns Hopkins Univ, Div Nephrol, Baltimore, MD 21218 USA

来源：

NEPHROLOGY DIALYSIS TRANSPLANTATION | 2024年 / 40卷 / 03期

关键词：

acute kidney injury; antibiotics; fecal microbiota transplantation; gut-kidney axis; gut microbiome; BLOOD-PRESSURE;

D O I：

10.1093/ndt/gfae196

中图分类号：

R3 [基础医学]; R4 [临床医学];

学科分类号：

1001 ; 1002 ; 100602 ;

摘要：

The microbiome of critically ill patients is significantly altered by both effects of the illnesses and clinical interventions provided during intensive care. Studies have shown that manipulating the microbiome can prevent or modulate complications of critical illness in experimental models and preliminary clinical trials. This review aims to discuss general concepts about the microbiome, including mechanisms of modifying acute organ dysfunction. The focus will be on the effects of microbiome modulation during experimental acute kidney injury (excluding septic acute kidney injury) and comparison with other experimental acute organ injuries commonly seen in critically ill patients.

引用

页码：423 / 434

页数：12

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