Two new compounds from the roots of Paeonia lactiflora Pall. and their anti-inflammatory effects

被引：0

作者：

Fu, Bo ^{[1
]}

Zhang, Jin-Ling ^{[1
]}

Wu, Jia-Tong ^{[1
]}

Wang, Si-Yi ^{[1
]}

Zhang, Yi-Qiang ^{[1
]}

Pan, Juan ^{[1
]}

Guan, Wei ^{[1
]}

Hao, Zhi-Chao ^{[1
]}

Kuang, Hai-Xue ^{[1
]}

Chen, Qing-shan ^{[2
]}

Zhang, Li-Li ^{[2
]}

Yang, Bing-You ^{[1
]}

Liu, Yan ^{[1
]}

机构：

[1] Heilongjiang Univ Chinese Med, Key Lab Basic & Applicat Res Beiyao, Minist Educ, Tradit Chinese Med TCM Biol Genet Heilongjiang Pro, Harbin, Peoples R China

[2] Northeast Agr Univ, Coll Agr, Harbin, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2025年

关键词：

Lignan; benzofuran; <italic>Paeonia lactiflora</italic> Pall; anti-inflammatory; NEOLIGNAN GLYCOSIDES; CONSTITUENTS; RUBRA; LEAVES;

D O I：

10.1080/14786419.2025.2462114

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new compounds (1-2), together with six known ones (3-8), were isolated from the roots of Paeonia lactiflora Pall. The structures of two new compounds were elucidated based on HR-ESI-MS, UV, and NMR spectroscopic data analysis. Moreover, the anti-inflammatory activities of compounds 1-8 were determined using LPS-induced RAW 264.7 cells. Compounds 2, 6, and 8 showed the most potent inhibitory activities on NO production with IC50 values of 17.34 +/- 1.5, 27.22 +/- 1.3, and 14.79 +/- 1.7 mu M, respectively. Compounds 4 and 7 showed moderate inhibitory activities. Compounds 3 and 5 showed relatively weak inhibitory activities.

引用

页数：8

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