The crosstalk between primary MSCs and cancer cells in 2D and 3D cultures: potential therapeutic strategies and impact on drug resistance

被引：1
|
作者：
Rehman, Ayesha [1 ]
Panda, Sameer Kumar [1 ]
Torsiello, Martina
Marigliano, Martina [1 ,2 ]
Tufano, Camilla Carmela [1 ]
Nigam, Aditya [1 ]
Parveen, Zahida [1 ]
Papaccio, Gianpaolo [1 ]
La Noce, Marcella [1 ]
机构：
[1] Univ Campania L Vanvitelli, Dept Expt Med, Via L Armanni 5, I-80138 Naples, Italy
[2] Scuola Med Salernitana, Dept Med Surg & Dent, Via Salvador Allende 43, Salerno, Italy
来源：
STEM CELLS TRANSLATIONAL MEDICINE | 2024年
关键词：
MSCs; adipose stem cells; cancer stem cells; microenvironment; stem cell-microenvironment interaction; MESENCHYMAL STEM-CELLS; NANOPARTICLES; DELIVERY; TARGET; STROMA; RHOA;
D O I：
10.1093/stcltm/szae077
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
The tumor microenvironment (TME) significantly influences cancer progression, and mesenchymal stem cells (MSCs) play a crucial role in interacting with tumor cells via paracrine signaling, affecting behaviors such as proliferation, migration, and epithelial-mesenchymal transition. While conventional 2D culture models have provided valuable insights, they cannot fully replicate the complexity and diversity of the TME. Therefore, developing 3D culture systems that better mimic in vivo conditions is essential. This review delves into the heterogeneous nature of the TME, spotlighting MSC-tumor cellular signaling and advancements in 3D culture technologies. Utilizing MSCs in cancer therapy presents opportunities to enhance treatment effectiveness and overcome resistance mechanisms. Understanding MSC interactions within the TME and leveraging 3D culture models can advance novel cancer therapies and improve clinical outcomes. Additionally, this review underscores the therapeutic potential of engineered MSCs, emphasizing their role in targeted anti-cancer treatments. Graphical Abstract
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页数：8
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