Upadacitinib outperforms dupilumab in restoring the fungal microbiome in atopic dermatitis

被引：0
|
作者：
Li, Tingting [1 ,2 ,3 ]
Tao, Rong [4 ]
Yang, Li [1 ,2 ,3 ]
Wan, Zhe [1 ,2 ,3 ]
Li, Ruoyu [1 ,2 ,3 ]
Wang, Ruojun [1 ,2 ,3 ]
机构：
[1] Peking Univ First Hosp, Dept Dermatol, Beijing, Peoples R China
[2] Natl Clin Res Ctr Dermatol & Immunol Dis, Beijing, Peoples R China
[3] Peking Univ, Res Ctr Med Mycol, Beijing, Peoples R China
[4] Capital Med Univ, Beijing Tongren Hosp, Dept Dermatol, Beijing, Peoples R China
来源：
BRITISH JOURNAL OF DERMATOLOGY | 2025年
关键词：
MGL-1304;
D O I：
10.1093/bjd/ljaf095
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Our study is the first to compare fungal microbiome changes in patients with atopic dermatitis (AD) before and after treatment with upadacitinib and dupilumab. We found that upadacitinib more effectively restores the fungal microbiome to levels observed in healthy individuals, which may contribute to its superior efficacy in head-and-neck dermatitis (a subtype of AD). The results enhance our understanding of how JAK inhibitors influence the skin microbiome in AD.
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页数：2
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