Does glial lipid dysregulation alter sleep in Alzheimer's ' s and Parkinson's ' s disease?

被引:1
|
作者
Goodman, Lindsey D. [1 ,2 ]
Moulton, Matthew J. [1 ,2 ]
Lin, Guang [1 ,2 ]
Bellen, Hugo J. [1 ,2 ,3 ,4 ]
机构
[1] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA
[2] Texas Childrens Hosp, Jan & Dan Duncan Neurol Res Inst, Houston, TX 77030 USA
[3] Baylor Coll Med, Program Dev Biol, Houston, TX 77030 USA
[4] Baylor Coll Med, Dept Neurosci, Houston, TX 77030 USA
关键词
DROSOPHILA; ACCUMULATION; RISK; LRP1;
D O I
10.1016/j.molmed.2024.04.010
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In this opinion article, we discuss potential connections between sleep disturbances observed in Alzheimer's disease (AD) and Parkinson's disease (PD) and the dysregulation of lipids in the brain. Research using Drosophila has highlighted the role of glial-mediated lipid metabolism in sleep and diurnal rhythms. Relevant to AD, the formation of lipid droplets in glia, which occurs in response to elevated neuronal reactive oxygen species (ROS), is required for sleep. In disease models, this process is disrupted, arguing a connection to sleep dysregulation. Relevant to PD, the degradation of neuronally synthesized glucosylceramides by glia requires glucocerebrosidase (GBA, a PD-associated risk factor) and this regulates sleep. Loss of GBA in glia causes an accumulation of glucosylceramides and neurodegeneration. Overall, research primarily using Drosophila has highlighted how dysregulation of glial lipid metabolism may underlie sleep disturbances in neurodegenerative diseases.
引用
收藏
页码:913 / 923
页数:11
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