The current Indian Standard Seismic Code IS 1893: Part 1 (2016) for general buildings lacks detailed guidelines on modeling soil-structure interaction (SSI) in the estimation of seismic demand and earthquake-induced damage in reinforced concrete buildings. Therefore, this study aims to investigate the effects of SSI, with a focus on its nonlinear behavior, on the seismic demand of ductile reinforced concrete frames designed as per IS 1893: Part 1. The selected RC buildings are designed for second-highest seismic risk zone in India and represent short, medium, and long-period structures commonly found across Indian sub-continent. The influence of SSI is studied for soil type II and type III, as specified in the Indian Code, which corresponds to medium stiff and soft soil sites, respectively. Using a nonlinear Winkler-based model, numerical finite element models of linear and nonlinear SSI have been developed for isolated shallow foundations. This study utilizes the results of incremental dynamic analysis to evaluate the fragility parameters for code specified performance limit states. Further, the estimated fragility parameters are integrated with the regional hazard curve coefficients to quantify the annual exceedance probability of specified damage levels. The simulation results highlight the critical impact of nonlinear SSI on the earthquake resilience of IS code designed low- to high-rise reinforced concrete buildings. Notably, the percentage increase in estimated fragilities is higher for low-rise buildings than high-rise buildings when subjected to ground motions on soil sites. Additionally, the vulnerability to failure of these buildings elevates significantly when they are analyzed on soft soil sites compared to medium soil and bedrock sites. Therefore, it is recommended to account for the significance of nonlinear SSI while assessing the expected structural performance and fragility of IS 1893: Part 1 designed stiff low- to medium-rise reinforced concrete buildings, as this step can substantially enhance the resiliency of such buildings in the aftermath of a disastrous earthquake.