Association between estimated glucose disposal rate and kidney function decline in different glucose tolerance statuses from the 4 C study

被引：0

作者：

Luo, Peiqiong ^{[1
,2
]}

Li, Danpei ^{[1
,2
]}

Guo, Yaming ^{[1
,2
]}

Meng, Xiaoyu ^{[1
,2
]}

Kan, Ranran ^{[1
,2
]}

Yu, Xuefeng ^{[1
,2
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Div Endocrinol,Dept Internal Med, 1095 Jiefang Ave, Wuhan 430030, Hubei, Peoples R China

[2] Branch Natl Clin Res Ctr Metab Dis, Wuhan 430030, Hubei, Peoples R China

来源：

ACTA DIABETOLOGICA | 2024年

基金：

中国国家自然科学基金;

关键词：

Estimated glucose disposal rate; Glucose tolerance statuses; Kidney function decline; Insulin resistance; INSULIN-RESISTANCE; DISEASE; RISK; POPULATION; SURVIVAL; EQUATION;

D O I：

10.1007/s00592-024-02432-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

AimsTo investigate the association between estimated glucose disposal rate (eGDR) and kidney function decline among populations with different glucose tolerance statuses including normal glucose tolerance (NGT), prediabetes, and diabetes.MethodsThe present study analyzed 5,069 participants from a cohort study. The association between eGDR and kidney function decline was assessed using binary logistic regression. Restricted cubic splines (RCS) analyses were also performed to investigate the dose-dependent associations.ResultsDuring up to 5 years of follow-up, 116 (2.30%) individuals experienced kidney function decline. Binary logistic regression showed that an increased level of eGDR was associated with decreased risk of kidney function decline after full adjustment, in all participants (Q4 vs. Q1 HR 0.13, 95% CI 0.05-0.30, p = 0.001), prediabetes (Q4 vs. Q1HR 0.11, 95% CI 0.01-0.44, p = 0.007), and diabetes (Q4 vs. Q1 HR 0.06, 95% CI 0.00-0.37, p = 0.012), but not in those with NGT. RCS analyses suggested dose-dependent relationships of eGDR with the risk of kidney function decline in all participants (L-shaped curve) and those with prediabetes (inverted U-shaped curve) and diabetes (L-shaped curve).ConclusionsThe association between elevated baseline eGDR and reduced risk of kidney function decline was significant in participants with prediabetes and diabetes, but not in those with NGT. These dose-dependent associations may have important implications for the assessment of high-risk patients by healthcare professionals and may lead to the development of more tailored and effective prevention strategies.

引用

页数：10