Injectable polydopamine/curcumin dual-modified polylactic acid/ polycaprolactone coaxial staple fibers for chronotropic treatment of oral squamous cell carcinoma

Oral squamous cell carcinoma (OSCC) is one of the most prevalent malignant tumors in the oral and maxillofacial region. Traditional treatments for OSCC, including surgery, radiotherapy, and chemotherapy, often lead to severe adverse effects. Therefore, the development of safe and effective novel cancer therapies is crucial for achieving synergistic cancer treatment, significantly enhancing patient survival and quality of life. In this study, triaxial electrospinning combined with freeze-shortening technology was employed to prepare injectable short fibers that provided a sustained release of curcumin (CUR). Subsequently, polydopamine (PDA) was modified on the surface of the short fibers to create PDA@CUR@PCL/PLA. The developed injectable short fibers represented a significant advancement in reducing the risks associated with the surgical implantation of traditional two-dimensional fibrous membranes. These fibers were coated with dopamine, which imparted notable significant photothermal effects, facilitating the rapid destruction of cancer cells. Furthermore, the core-loaded CUR was released in a pH-responsive manner and demonstrated a sustained anti-tumor effect. Cellular and animal experiments indicated that these composite short fibers could effectively eliminate oral cancer cells through a synergistic combination of photothermal and drug therapies without apparent toxic side effects. The developed injectable coaxial PDA@CUR@PCL/PLA short fibers are expected to provide a novel treatment approach for OSCC.