Diabetes mellitus is a chronic metabolic disease associated with numerous complications, including diabetic keratopathy. This frequently underestimated disease can lead to reduced corneal sensitivity, neurotrophic ulcers and potentially sight-threatening infections. In this retrospective analysis of the subgroup of 136,992 machine-readable health records recruited from all patients who presented to our university outpatient clinic between January 2003 and February 2024, we investigated the association between diabetes mellitus, neurotrophic keratopathy and corneal ulcers. Of the patients 3168 had corneal ulcers (prevalence 2.3%) and 11,338 had diabetes mellitus (8%). The results showed that diabetes mellitus significantly increased the risk of corneal ulcers (odds ratio, OR 1.18; 95% confidence interval, CI 1.04-1.32) and neurotrophic keratopathy (OR 1.78; 95% CI 1.20-2.56). In addition, older age and male gender were risk factors. In the reverse analysis, corneal ulcers were shown to be significant predictors of the presence of diabetes mellitus. Our results underline the need for regular ophthalmological check-ups and diabetes mellitus screening in patients with corneal complications in order to intervene at an early stage and prevent severe consequences such as loss of vision.
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Royal Adelaide Hosp, South Australian Inst Ophthalmol, Adelaide, AustraliaRoyal Adelaide Hosp, South Australian Inst Ophthalmol, Adelaide, Australia
Aujla, Jaskirat
Tong, Jessica Y.
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Royal Adelaide Hosp, South Australian Inst Ophthalmol, Adelaide, Australia
Royal Adelaide Hosp, Dept Plast & Reconstruct Surg, Adelaide, AustraliaRoyal Adelaide Hosp, South Australian Inst Ophthalmol, Adelaide, Australia
Tong, Jessica Y.
Curragh, David
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Royal Adelaide Hosp, South Australian Inst Ophthalmol, Adelaide, AustraliaRoyal Adelaide Hosp, South Australian Inst Ophthalmol, Adelaide, Australia
Curragh, David
Caplash, Yugesh
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Royal Adelaide Hosp, Dept Plast & Reconstruct Surg, Adelaide, AustraliaRoyal Adelaide Hosp, South Australian Inst Ophthalmol, Adelaide, Australia
Caplash, Yugesh
Chehade, Mark
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Royal Adelaide Hosp, South Australian Inst Ophthalmol, Adelaide, AustraliaRoyal Adelaide Hosp, South Australian Inst Ophthalmol, Adelaide, Australia
Chehade, Mark
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Tumuluri, Krishna
Au, Alicia
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Monash Hlth, Clayton, Vic, AustraliaRoyal Adelaide Hosp, South Australian Inst Ophthalmol, Adelaide, Australia
Au, Alicia
Low, Nelson
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Rabin Med Ctr, Tel Aviv, IsraelRoyal Adelaide Hosp, South Australian Inst Ophthalmol, Adelaide, Australia
Low, Nelson
Avisar, Inbal
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Rabin Med Ctr, Tel Aviv, IsraelRoyal Adelaide Hosp, South Australian Inst Ophthalmol, Adelaide, Australia
Avisar, Inbal
Sagiv, Oded
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Sheba Med Ctr, Goldschleger Eye Inst, Tel Hashomer, Israel
Univ Texas MD Anderson Canc Ctr, Dept Head & Neck Surg, Sect Ophthalmol, Houston, TX USARoyal Adelaide Hosp, South Australian Inst Ophthalmol, Adelaide, Australia
Sagiv, Oded
Barequet, Irit
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Sheba Med Ctr, Goldschleger Eye Inst, Tel Hashomer, IsraelRoyal Adelaide Hosp, South Australian Inst Ophthalmol, Adelaide, Australia
Barequet, Irit
Ben Simon, Guy
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Sheba Med Ctr, Goldschleger Eye Inst, Tel Hashomer, IsraelRoyal Adelaide Hosp, South Australian Inst Ophthalmol, Adelaide, Australia
Ben Simon, Guy
Selva, Dinesh
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Royal Adelaide Hosp, South Australian Inst Ophthalmol, Adelaide, AustraliaRoyal Adelaide Hosp, South Australian Inst Ophthalmol, Adelaide, Australia
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Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Ophthalmol, Beijing 100005, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Ophthalmol, Beijing 100005, Peoples R China
Chang, Yuan
Zhang, Tao
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Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Stomatol, Beijing 100005, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Ophthalmol, Beijing 100005, Peoples R China
Zhang, Tao
Liu, Xiaowei
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Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Ophthalmol, Beijing 100005, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Ophthalmol, Beijing 100005, Peoples R China