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Antibiotic Resistance of Helicobacter pylori in Mainland China: A Focus on Geographic Differences Through Systematic Review and Meta-Analysis
被引:1
|作者:
Zeng, Shuyan
[1
,2
]
Kong, Qingzhou
[1
,2
]
Wu, Xiaoqi
[1
,2
]
Duan, Miao
[1
,2
]
Nan, Xueping
[1
,2
]
Yang, Xiaoyun
[1
,2
]
Zuo, Xiuli
[1
,2
]
Li, Yueyue
[1
,2
]
Li, Yanqing
[1
,2
]
机构:
[1] Shandong Univ, Dept Gastroenterol, Qilu Hosp, 107 Wenhuaxi Rd, Jinan 250012, Shandong, Peoples R China
[2] Shandong Univ, Shandong Prov Clin Res Ctr Digest Dis, Qilu Hosp, Jinan, Shandong, Peoples R China
关键词:
Antibiotic resistance mapping;
Helicobacter pylori;
China;
Primary resistance;
Secondary resistance;
AMOXICILLIN;
INFECTION;
CONSENSUS;
D O I:
10.1016/j.ijantimicag.2024.107325
中图分类号:
R51 [传染病];
学科分类号:
100401 ;
摘要:
Background: Empirical treatment needs to be supported by regional data, but knowledge of interregional differences is currently lacking in China. This study aimed to summarize and map the primary and secondary antibiotic resistance of Helicobacter pylori in different regions of mainland China. Methods: PubMed, EMBASE, Web of Science, China National Knowledge Infrastructure and Wanfang databases were systematically reviewed for studies published between 1 January 20 0 0 and 15 July 2023. Data related to primary and secondary H. pylori antibiotic resistance rates were included. Random-effects models were used to synthesize the pooled resistance rates. Results: Ultimately, 74 studies were included in the final analysis. A total of 16 provinces reported resistance data. The overall resistance rates of H. pylori in mainland China were 30.72% (95% CI 27.53%-33.99%) to clarithromycin, 70.14% (95% CI 29.53%-37.46%) to metronidazole and 32.98% (95% CI 28.73%-37.37%) to levofloxacin; for amoxicillin, tetracycline, and furazolidone, the rates were 2.41% (95% CI 1.43%-3.60%), 2.53% (95% CI 1.19%-4.28%) and 1.54% (95% CI 0.28%-3.62%), respectively. Spatial and temporal differences were observed. The resistance rates increased after treatment failure; however, secondary resistance to amoxicillin, tetracycline and furazolidone were still low across the vast majority of study regions. Conclusion: Surveillance of the updated prevalence of antibiotic resistance of H. pylori for different regions is warranted, which should factor into clinical decision making and guideline recommendations. (c) 2024 Elsevier Ltd and International Society of Antimicrobial Chemotherapy. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
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