Artificial Intelligence (AI) Applications in Drug Discovery and Drug Delivery: Revolutionizing Personalized Medicine

被引:13
|
作者
Serrano, Dolores R. [1 ,2 ]
Luciano, Francis C. [1 ]
Anaya, Brayan J. [1 ]
Ongoren, Baris [1 ]
Kara, Aytug [1 ]
Molina, Gracia [1 ]
Ramirez, Bianca I. [1 ]
Sanchez-Guirales, Sergio A. [1 ]
Simon, Jesus A. [1 ]
Tomietto, Greta [1 ]
Rapti, Chrysi [1 ]
Ruiz, Helga K. [1 ]
Rawat, Satyavati [3 ]
Kumar, Dinesh [3 ]
Lalatsa, Aikaterini [4 ,5 ]
机构
[1] Univ Complutense Madrid, Sch Pharm, Dept Pharmaceut & Food Sci, Madrid 28040, Spain
[2] Inst Univ Farm Ind, Madrid 28040, Spain
[3] Indian Inst Technol BHU, Dept Pharmaceut Engn & Technol, Varanasi 221005, India
[4] Univ Strathclyde, Inst Pharm & Biomed Sci, 161 Cathedral St, Glasgow G4 0RE, Scotland
[5] Univ Strathclyde, Sch Pharm & Biomed Sci, CRUK Formulat Unit, 161 Cathedral St, Glasgow G4 0RE, Scotland
关键词
artificial intelligence; AI; drug delivery; drug development; target identification; lead optimization; personalized medicines; IN-VITRO; IDENTIFICATION; TRANSFORMER; FORMULATION; ACCELERATE; MODELS; VIVO;
D O I
10.3390/pharmaceutics16101328
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Artificial intelligence (AI) encompasses a broad spectrum of techniques that have been utilized by pharmaceutical companies for decades, including machine learning, deep learning, and other advanced computational methods. These innovations have unlocked unprecedented opportunities for the acceleration of drug discovery and delivery, the optimization of treatment regimens, and the improvement of patient outcomes. AI is swiftly transforming the pharmaceutical industry, revolutionizing everything from drug development and discovery to personalized medicine, including target identification and validation, selection of excipients, prediction of the synthetic route, supply chain optimization, monitoring during continuous manufacturing processes, or predictive maintenance, among others. While the integration of AI promises to enhance efficiency, reduce costs, and improve both medicines and patient health, it also raises important questions from a regulatory point of view. In this review article, we will present a comprehensive overview of AI's applications in the pharmaceutical industry, covering areas such as drug discovery, target optimization, personalized medicine, drug safety, and more. By analyzing current research trends and case studies, we aim to shed light on AI's transformative impact on the pharmaceutical industry and its broader implications for healthcare.
引用
收藏
页数:27
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