Complement regulation in tumor immune evasion

被引：0
|
作者：
Liu, Guijun [1 ,2 ,3 ]
He, Xuxiao [1 ,2 ,3 ]
Zhao, Gaoxiang [4 ]
Lu, Zhimin [1 ,2 ,3 ]
机构：
[1] Zhejiang Univ, Affiliated Hosp 1, Inst Translat Med, Sch Med,Zhejiang Key Lab Pancreat Dis,Zhejiang Key, Hangzhou 310029, Zhejiang, Peoples R China
[2] Zhejiang Univ, Inst Fundamental & Transdisciplinary Res, Hangzhou 310029, Zhejiang, Peoples R China
[3] Zhejiang Univ, Canc Ctr, Hangzhou 310029, Zhejiang, Peoples R China
[4] Qingdao Univ, Affiliated Hosp, Canc Inst, Qingdao Canc Inst,Dept Oncol, Qingdao 266061, Shandong, Peoples R China
来源：
SEMINARS IN IMMUNOLOGY | 2024年 / 76卷
基金：
中国博士后科学基金;
关键词：
Complement system; Immunity; Immune cells; Tumor; Tumor microenvironment; MCRP; CHRONIC LYMPHOCYTIC-LEUKEMIA; BREAST-CANCER CELLS; FACTOR-H; FACTOR-I; DEPENDENT CYTOTOXICITY; LUNG-CANCER; MONOCLONAL-ANTIBODIES; ANTITUMOR-ACTIVITY; HUMAN MACROPHAGE; CARCINOMA-CELLS;
D O I：
10.1016/j.smim.2024.101912
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The complement system plays crucial roles in both innate and adaptive immune responses, facilitating the elimination of pathogens such as microorganisms and damaged cells, including cancer cells. It is tightly regulated and integrated with cell-mediated immunity. In the tumor microenvironment, the complement system performs both immune and nonimmune functions in tumor and immune cells through pathways that depend on or are independent of complement activation, thereby promoting immune evasion and tumor progression.
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页数：11
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