Rhodium-catalyzed C-H α-fluoroalkenylation/annulation of β-ketosulfoxonium ylides with 2,2-difluorovinyl tosylate/oxadiazolones

被引：1

作者：

Song, Jia-Lin ^{[1
,2
]}

Yang, Zi-Feng ^{[3
]}

Fang, Sheng ^{[1
]}

Chen, Wang-Liang ^{[1
]}

Ye, Lian-Bao ^{[1
]}

Liu, Xiang ^{[3
]}

Shu, Bing ^{[1
,4
]}

机构：

[1] Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Peoples R China

[2] Sun Yat Sen Univ, Sch Chem, Guangzhou 510006, Peoples R China

[3] Guangdong Pharmaceut Univ, Sch Chem & Chem Engn, Zhongshan 528458, Peoples R China

[4] Guangdong Pharmaceut Univ, Guangdong Prov Key Lab Res & Evaluat Pharmaceut Pr, Guangzhou 510006, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 100期

关键词：

CARBONYL SULFOXONIUM YLIDES; FUNCTIONALIZATION; CYCLIZATION; ACTIVATION; ANNULATION;

D O I：

10.1039/d4cc05621c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A Rh(iii)-catalyzed C-H alpha-fluoroalkenylation/annulation of beta-ketosulfoxonium ylides with 2,2-difluorovinyl tosylate/oxadiazolones was realized, which afforded various o-fluoroalkenylation beta-ketosulfoxonium ylides with high Z-selectivity and diverse oxadiazolone fused-isoquinolines. This protocol featured mild conditions, broad substrate scope, and functional-group compatibility. In addition, scale-up synthesis, related applications and preliminary mechanistic explorations were also accomplished.

引用

页码：15000 / 15003

页数：4

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