Characterization, antifungal activity, and possible action mechanism of Melissa officinalis essential oil against Candida spp. and Cryptococcus neoformans strains

被引：0

作者：

Cavalcanti, Bruno Coelho ^{[1
]}

Magalhaes, Islay Lima ^{[1
]}

Follone, Ingrid de Carvalho ^{[2
]}

Araujo, alvaro Gabriel de Souza ^{[2
]}

Correia, Marcos Vinicius Queiroz Ambrosio ^{[2
]}

Rodrigues, Daniel Sampaio ^{[1
,3
,4
]}

Cabral, Vitoria Pessoa de Farias ^{[1
,3
,4
]}

Moreira, Lara Elloyse Almeida ^{[1
,3
]}

Sa, Livia Gurgel do Amaral Valente ^{[1
,3
]}

Neto, Joao Batista de Andrade ^{[1
,3
,4
]}

da Silva, Cecilia Rocha ^{[1
,3
]}

de Moraes, Manoel Odorico ^{[1
]}

dos Santos, Claudio Costa ^{[1
,2
]}

Nobre Junior, Helio Vitoriano ^{[1
,3
]}

机构：

[1] Univ Fed Ceara, Drug Res & Dev Ctr NPDM, BR-60430275 Fortaleza, CE, Brazil

[2] Fed Univ Semiarid Reg, Dept Engn & Technol, BR-59625900 Mossoro, RN, Brazil

[3] Univ Fed Ceara, Sch Pharm, Lab Bioprospect Antimicrobial Mol LABIMAN, BR-60430370 Fortaleza, CE, Brazil

[4] Christus Univ Ctr UNICHRISTUS, BR-60190180 Fortaleza, CE, Brazil

来源：

LETTERS IN APPLIED MICROBIOLOGY | 2025年 / 78卷 / 04期

关键词：

Melissa officinalis; essential oil; antifungal activity; mechanisms of action; CHEMICAL-COMPOSITION; FLUCONAZOLE; RESISTANT;

D O I：

10.1093/lambio/ovaf040

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

This study aimed to characterize Melissa officinalis essential oil (EOMO) from a region in Northeast Brazil and evaluate its antifungal activity against Candida and Cryptococcus neoformans, by analyzing its action mechanism. EOMO was characterized using gas chromatography-mass spectrometry and the main chemical compounds were Geranial (14.10%) and (Z)-Nerolidol (17.75%). The broth microdilution assay was used to determine the minimum inhibitory concentration (MIC) against strains of Candida albicans, Candida parapsilosis, Candida krusei, Candida auris (MIC raging from 256 to 26.7 mu g ml-1) and C. neoformans (MIC ranging from 64 to 32 mu g ml-1). Flow cytometry and comet assays were employed to investigate EOMO's mechanism of action, which might be related to an increase in the production of reactive oxygen species and damage to fungal DNA. The chemical composition of EOMO from Northeast Brazil showed a higher content of (Z)-Nerolidol and has significant antifungal potential.

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页数：10

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