Diterpenoids from Mangrove Plant Excoecaria agallocha L. and Their Anti-neuroinflammatory Activities

被引：1

作者：

Li, Junyi ^{[1
]}

Lu, Yang ^{[2
]}

Chen, Mingbin ^{[1
]}

Rao, Yong ^{[1
]}

Jiang, Zhongping ^{[1
]}

Huang, Ling ^{[1
]}

机构：

[1] Hainan Univ, Sch Pharmaceut Sci, Key Lab Trop Biol Resources Minist Educ, Haikou 570228, Peoples R China

[2] Hainan Univ, Sch Food Sci & Engn, Haikou 570228, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 44卷 / 11期

关键词：

Excoecaria agallocha L; mangrove plant; kaurane diterpenoid; labdane diterpenoid; anti-neuroimflamation;

D O I：

10.6023/cjoc202404024

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Normal-phase and reversed-phase silica gel column chromatography and semi-preparative high performance liquid chromatography were applied to study the chemical constituents of the stems and twigs of the Hainan mangrove plant, Excoecaria agallocha L. A new 3,4-seco-ent-kaurane diterpenoid, named agallochanin acid A (1), and a rare ent-tetranorlabdane diterpenoid, named agallochanin acid B (2), along with four known diterpenoids were isolated. Their structures including absolute configurations were characterized via HR-ESI-MS, extensive 1D and 2D NMR investigations and calculated and experimental electronic circular dichroism (ECD) data. All isolates were tested for their inhibitory effects on NO production in lipopolysaccharide (LPS)-activated BV-2 cells. ent-3,4-Seco-17-oxo-kaur-4(19),15(16)-dien-3-oic acid (3) and ent-15-hydroxy- labda-8(17),13E-dien-3-one (5) exhibited considerable anti-neuroinflammatory activities with IC50 values of (14.32 +/- 1.99) and (4.24 +/- 0.37) mu mol/L.

引用

页码：3526 / 3530

页数：5