Respiratory syncytial virus infection among children younger than 2 years admitted to a paediatric intensive care unit with extended severe acute respiratory infection in ten Gavi-eligible countries: the RSV GOLD-ICU Network study

被引：5

作者：

Abdelrahman, Dina N. ^{[1
]}

Abdullahi, Fatima L. ^{[2
]}

Abdu-Raheem, Fadlulai ^{[2
]}

Abicher, Lynda T. ^{[3
]}

Adelaiye, Hamdalla ^{[2
]}

Badjie, Ansumana ^{[4
]}

Bah, Abdou ^{[4
]}

Bista, Krishna P. ^{[5
]}

Bont, Louis J. ^{[6
]}

Boom, Trisja T. ^{[6
]}

Buck, W. Chris ^{[7
,8
]}

Caceres Avila, Milka Amanda ^{[9
]}

Chapagain, Ram Hari ^{[5
]}

Cianci, Daniela ^{[6
,10
]}

Deroncelay, Alexandra ^{[3
]}

Dor, Vanessa ^{[3
]}

Ekotto, Karen ^{[11
]}

Enan, Khalid A. ^{[1
]}

Eposse, Charlotte ^{[11
]}

Fouobang, Esquivel ^{[11
]}

Gai, Abdou ^{[4
]}

Garba, Abdoulie ^{[4
]}

Garba, Maria A. ^{[2
]}

Gautier, Jacqueline ^{[3
]}

Giwa, Fatima J. ^{[2
]}

Godfrey, Evance K. ^{[13
]}

Goka, Bamenla Quarm ^{[12
]}

Jaiteh, Musa ^{[4
]}

Jallow, Mariama ^{[4
]}

Jallow, Alasana ^{[4
]}

Joof, Sheikh ^{[4
]}

Joshi, Prakash ^{[5
]}

Kuti, Bankole P. ^{[4
]}

Lowensteyn, Yvette N. ^{[6
]}

Makalo, Lamin ^{[4
]}

Mandi, Henshaw ^{[11
]}

Manjate, Yara ^{[14
]}

Manjate, Elias ^{[14
]}

Matimbe, Izilda ^{[14
]}

Mazur, Natalie I. ^{[6
]}

Medani, Safaa A. ^{[17
]}

Mendy, Peter T. ^{[4
]}

Muando, Valeria ^{[7
]}

Mussa, Tufaria ^{[14
]}

Nair, Harish ^{[15
]}

Nyan, Ousman ^{[4
]}

Obodai, Evangeline ^{[16
]}

Olorukooba, Aira A. ^{[2
]}

Osman, Kwabena Agyapong ^{[12
]}

Osman, Khalid ^{[17
]}

机构：

[1] Minist Highger Educ & Sci Res, Dept Virol, Cent Lab, Khartoum, Sudan

[2] Ahmadu Bello Univ Teaching Hosp, Dept Pediat, Zaria, Nigeria

[3] St Damien Hosp, Dept Pediat, Port Au Prince, Haiti

[4] Edward Francis Small Teaching Hosp, Dept Pediat, Banjul, Gambia

[5] Kanti Childrens Hosp, Kathmandu, Nepal

[6] Univ Med Ctr Utrcht, Dept Pediat Infect Dis & Immunol, Wilhelmina Childrens Hosp, NL-3508 AB Utrecht, Netherlands

[7] Maputo Cent Hosp, Dept Pediat, Maputo, Mozambique

[8] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA USA

[9] Childrens Hosp Dr Mario Ortiz Suarez, Dept Pediat Intens Care, Santa Cruz, Bolivia

[10] Univ Utrecht, Julius Ctr Hlth Sci & Primary Car, Dept Data Sci & Biostat, Univ Med Ctr Utrcht, Utrecht, Netherlands

[11] Laquintinie Hosp, Dept Pediat, Douala, Cameroon

[12] Uni Ghana, Sch Med, Dept Child Hlth, Korle Bu Teaching Hosp, Accra, Ghana

[13] Muhimbili Natl Hosp, Dept Pediat Intens Care, Dar Es Salaam, Tanzania

[14] Eduardo Mondlane Univ, Fac Med, Maputo, Mozambique

[15] Univ Edinburgh, Ctr Global Hlth, Usher Inst, Edinburgh, Midlothian, Scotland

[16] Univ Ghana, Noguchi Mem Inst Med Res, Accra, Ghana

[17] Jafar Ibn Auf Specialized Hosp Children, Dept Pediat Intens Care, Khartoum, Sudan

[18] Tribhuvan Univ Teaching Hos, Inst Med, Dept Pediat Intens Care, Kathmandu, Nepal

[19] Amsterdam Univ Med Ctr, Dept Pediat Intens Care, Amsterdam, Netherlands

来源：

LANCET GLOBAL HEALTH | 2024年 / 12卷 / 10期

基金：

比尔及梅琳达.盖茨基金会;

关键词：

COHORT;

D O I：

10.1016/S2214-109X(24)00269-9

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background Patient-level data on life-threatening respiratory syncytial virus (RSV) infection in children in low-income and lower-middle-income countries (LMICs) are scarce, and this scarcity might limit demand for RSV interventions in LMICs who rely on support from Gavi, the Vaccine Alliance. We aimed to describe the characteristics of RSV- positive children younger than 2 years who were admitted to paediatric intensive care units (PICUs) with extended severe acute respiratory infection (eSARI) in Gavi-eligible countries. Methods The RSV GOLD-ICU Network study is a 2-year prospective, multicountry, observational study of children younger than 2 years admitted to a PICU with eSARI. The study was conducted at 12 referral hospitals in Bolivia, Cameroon, The Gambia, Ghana, Haiti, Mozambique, Nepal, Nigeria, Sudan, and Tanzania. For comparison with a high-income country, patients were also included from two referral hospitals in the Netherlands. Children were eligible for inclusion if they were aged between 4 days and 2 years, admitted to a PICU, and met the WHO eSARI definition. RSV infection was confirmed within 72 h of PICU admission via a molecular point-of-care test at LMIC study sites and via a PCR test at the Dutch study sites. Clinical data were extracted from admission charts of patients; underlying conditions that were identified at admission were classified as comorbidities. Socioeconomic and demographic data were collected via a written, structured, parental questionnaire. Findings Between April 28, 2021, and Sept 30, 2023, we included 2118 children who were admitted to a PICU with eSARI in the ten participating countries. 614 (290%; range 230-382) of 2118 children tested positive for RSV and 608 were included in descriptive analyses as six medical files were lost at one study site and data could not be retrieved. Among all 608 children infected with RSV, 379 (62%) were male and 229 (38%) were female. Median age at testing was 30 months (IQR 13-77). 30 (5%) of 608 children died from RSV infection. RSV fatality occurred at seven of ten participating LMIC study sites and was highest in Tanzania (seven [27%] of 26 children). Median age at testing of children who died with RSV infection was 18 months (IQR 11-42). Interpretation To our knowledge, this is the first prospective, multicountry study reporting data from children admitted to a PICU with life-threatening RSV infection in Gavi-eligible countries. As there is no access to intensive care for most children in LMICs, RSV prevention is urgently needed. Copyright (c) 2024 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.

引用

页数：9

共 5 条

[1] Severe RSV infection among children younger than 2 years admitted to the paediatric intensive care unit in low- and lower-middle-income countries
Lowensteyn, Yvette
Rave, Neele
Willemsen, Joukje
Mazur, Natalie
Nair, Harish
Bont, Louis
TROPICAL MEDICINE & INTERNATIONAL HEALTH, 2023, 28 : 353 - 353
[2] Health and economic burden of respiratory syncytial virus (RSV) disease and the cost-effectiveness of potential interventions against RSV among children under 5 years in 72 Gavi-eligible countries
Xiao Li
Lander Willem
Marina Antillon
Joke Bilcke
Mark Jit
Philippe Beutels
BMC Medicine, 18
[3] Health and economic burden of respiratory syncytial virus (RSV) disease and the cost-effectiveness of potential interventions against RSV among children under 5 years in 72 Gavi-eligible countries
Li, Xiao
Willem, Lander
Antillon, Marina
Bilcke, Joke
Jit, Mark
Beutels, Philippe
BMC MEDICINE, 2020, 18 (01)
[4] Viral Aetiology of Severe Acute Lower Respiratory Tract Infection in Children from the Paediatric Intensive Care Unit at a Tertiary Care Hospital, Eastern India- A Retrospective Study
Ahuja, Neha
Gorain, Somenath
Pal, Partha Pratim
Das, Mousumi
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2022, 16 (10) : SC06 - SC10
[5] A Study on the Safety of Percutaneous Tracheostomy in Patients with Severe Acute Respiratory Syndrome Novel Corona Virus 2 (SARS-nCoV2) Infection: A Single-Center Observational Cohort Study in a CoVID Intensive Care Unit
Krishna Kumar Mylavarapu
Aditya Joshi
Ranjith Nair
Rangraj Setlur
Rajan Kapoor
SN Comprehensive Clinical Medicine, 2021, 3 (10) : 2082 - 2087

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